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    RAD28 Rad28p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851594, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RAD28
    Gene description
    Rad28p
    Primary source
    FungiDB:YDR030C
    Locus tag
    YDR030C
    See related
    SGD:S000002437; AllianceGenome:SGD:S000002437; VEuPathDB:YDR030C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RAD28 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (501753..503273, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator REG1 Neighboring gene uncharacterized protein Neighboring gene Mix14p Neighboring gene flavodoxin-like fold family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. Bhatia PK, et al. J Bacteriol, 1996 Oct. PMID 8830695, Free PMC Article
    2. Functional analysis of six ORFs from Saccharomyces cerevisiae chromosome IV: two-spored asci produced by disruptant of YDR027c and strain-dependent DNA heterogeneity around YDR036c. Aittamaa M, et al. Yeast, 2001 Jul. PMID 11447599
    3. A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair. Wong JM, et al. Mol Gen Genet, 2001 Feb. PMID 11254132
    4. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics. Kim JH, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33010166, Free PMC Article
    5. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Collins SR, et al. Nature, 2007 Apr 12. PMID 17314980

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-excision repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rad28p
    NP_010313.3
    • Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      501753..503273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180338.3 → NP_010313.3  TPA: Rad28p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010313.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS14, Q12021
      UniProtKB/TrEMBL
      A0A8H8UMU8, B3LGN6, C8Z4V0, N1P805
      Conserved Domains (2) summary
      COG2319
      Location:1 → 386
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:198 → 233
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12021.1

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