ROX1 Rox1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ROX1
Gene description: Rox1p
Primary source: FungiDB:YPR065W
Locus tag: YPR065W
See related: SGD:S000006269; AllianceGenome:SGD:S000006269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: REO1
Summary: Enables DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription corepressor activity. Involved in cellular response to osmotic stress and negative regulation of transcription from RNA polymerase II promoter in response to stress. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human SOX12 (SRY-box transcription factor 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ROX1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (679693..680799)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2ADelta Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.
Title: Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.
We further show that, in a scenario where the activity of Yap1 or Rox1 is compromised, cells activate post-transcriptional mechanisms, involving the exoribonuclease Xrn1, to compensate the derepression of FET4
Title: Repression of the Low Affinity Iron Transporter Gene FET4: A NOVEL MECHANISM AGAINST CADMIUM TOXICITY ORCHESTRATED BY YAP1 VIA ROX1.
the ROX1 feedback circuit is tuned to respond to perturbations arising from natural genetic variation in addition to its role in induction behavior
Title: Negative feedback confers mutational robustness in yeast transcription factor regulation.
Mot3 and Rox1 are important for growth and modulation of ergosterol levels upon salt stress. Hog1, Mot3, and Rox1 repress ERG gene expression during osmotic stress.
Title: Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.
Data show that transcriptional adaptation from aerobiosis to hypoxia depends on ROX1 and IXR1 cross-regulation.
Title: Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3691 (e-PCR)
- UniSTS:474269

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to increased oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to osmotic stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rox1p

NP_015390.1

Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

679693..680799

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184162.1 → NP_015390.1 TPA: Rox1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015390.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W469, P25042

UniProtKB/TrEMBL

A0A8H4F8D6, B3LLB8, B5VTL3, N1NXL1

Conserved Domains (1) summary

cd01389
Location:9 → 88

MATA_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include the fungal mating type gene products MC, MATA1 and Ste11.