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    SHR3 Shr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851314, updated on 4-Aug-2024

    Summary

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    Gene symbol
    SHR3
    Gene description
    Shr3p
    Primary source
    FungiDB:YDL212W
    Locus tag
    YDL212W
    See related
    SGD:S000002371; AllianceGenome:SGD:S000002371; VEuPathDB:YDL212W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APF1
    Summary
    Enables unfolded protein binding activity. Involved in COPII-coated vesicle budding and protein folding. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SHR3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (78426..79058)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PRR2 Neighboring gene Nop6p Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. Kuehn MJ, et al. J Cell Biol, 1996 Nov. PMID 8909535, Free PMC Article
    2. Functional analysis of apf1 mutation causing defective amino acid transport in Saccharomyces cerevisiae. Horák J, et al. Biochem Mol Biol Int, 1993 Apr. PMID 8389634
    3. Mutation affecting activity of several distinct amino acid transport systems in Saccharomyces cerevisiae. Grenson M, et al. J Bacteriol, 1971 Feb. PMID 5541525, Free PMC Article
    4. SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast. Ljungdahl PO, et al. Cell, 1992 Oct 30. PMID 1423607
    5. Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of plasma membrane-endoplasmic reticulum junctions. Ring A, et al. Traffic, 2019 Oct. PMID 31336002

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ER-localized Shr3 is a selective co-translational folding chaperone necessary for amino acid permease biogenesis.
      Title: ER-localized Shr3 is a selective co-translational folding chaperone necessary for amino acid permease biogenesis.
    2. Data show that the membrane domain of Shr3p prevents amino acid permeases (AAPs) from aggregating, and plays a critical role in assisting AAPs to fold and attain tertiary structures required for ER exit.
      Title: Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.
    3. Shr3 prevents aggregation and facilitates the functional assembly of independently coexpressed N- and C-terminal fragments of the general AAP Gap1.
      Title: Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Shr3p
    NP_010069.1
    • Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      78426..79058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180272.1 → NP_010069.1  TPA: Shr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRE2, Q02774, Q12413
      UniProtKB/TrEMBL
      A6ZXC1, B3LH92, B5VF64, C7GSW5, C8Z6Q7, G2WBV5, N1P862
      Conserved Domains (1) summary
      pfam08229
      Location:6 → 188
      SHR3_chaperone; ER membrane protein SH3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02774.2

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