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    SRC1 Src1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854974, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SRC1
    Gene description
    Src1p
    Primary source
    FungiDB:YML034W
    Locus tag
    YML034W
    See related
    SGD:S000004497; AllianceGenome:SGD:S000004497; VEuPathDB:YML034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HEH1; YML033W
    Summary
    Predicted to enable chromatin binding activity. Involved in establishment of mitotic sister chromatid cohesion and maintenance of rDNA. Located in nuclear envelope. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (209525..212155)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cgi121p Neighboring gene AMP deaminase Neighboring gene recombinase RAD52 Neighboring gene Ndc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SRC1: an intron-containing yeast gene involved in sister chromatid segregation. Rodríguez-Navarro S, et al. Yeast, 2002 Jan 15. PMID 11754482
    2. Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Lokareddy RK, et al. Structure, 2015 Jul 7. PMID 26051712, Free PMC Article
    3. Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Webster BM, et al. Cell, 2014 Oct 9. PMID 25303532, Free PMC Article
    4. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
    5. Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism. Poon BP, et al. Front Genet, 2012. PMID 22876257, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
      Title: ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
    2. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
      Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
    3. Heh2 and Src1/Heh1 contain bipartite import sequences that associate intimately with the minor nuclear localization sequence-binding pocket of yeast importin alpha.
      Title: Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
    4. Heh1p has a role in the assembly or stability of the nuclear pore complexes, potentially through the formation of a lumenal bridge with Pom152p.
      Title: Lumenal interactions in nuclear pore complex assembly and stability.
    5. The inner nuclear membrane protein Src1 functions at the interface between subtelomeric gene expression and TREX-dependent messenger RNA export through the nuclear pore complexes.
      Title: The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Src1p
    NP_013679.1
    • Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      209525..212155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182391.1 → NP_013679.1  TPA: Src1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZE1, Q03707, Q03712
      UniProtKB/TrEMBL
      A6ZM29, B3LLL9, C7GT63
      Conserved Domains (2) summary
      cd12935
      Location:14 → 48
      LEM_like; LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins
      pfam09402
      Location:464 → 820
      MSC; Man1-Src1p-C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03707.2

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