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    SRM1 Ran guanyl-nucleotide exchange factor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852782, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SRM1
    Official Full Name
    Ran guanyl-nucleotide exchange factor
    Primary source
    SGD:S000003065
    Locus tag
    YGL097W
    See related
    AllianceGenome:SGD:S000003065; FungiDB:YGL097W; VEuPathDB:YGL097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MTR1; PRP20; TSM437
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in nucleocytoplasmic transport and nucleus organization. Located in chromatin; cytoplasm; and nucleus. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (321782..323230)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene SNAP receptor USE1 Neighboring gene tRNA-His Neighboring gene Tos8p Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins. Lee A, et al. J Cell Sci, 1993 Sep. PMID 8270631
    2. Nuclear PRP20 protein is required for mRNA export. Amberg DC, et al. EMBO J, 1993 Jan. PMID 7679070, Free PMC Article
    3. A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation. Aebi M, et al. Mol Gen Genet, 1990 Oct. PMID 2277633
    4. Analysis of yeast prp20 mutations and functional complementation by the human homologue RCC1, a protein involved in the control of chromosome condensation. Fleischmann M, et al. Mol Gen Genet, 1991 Jul. PMID 1865879
    5. Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient model. Akhtar N, et al. Mol Genet Genomics, 2001 Jul. PMID 11523802

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reveals that Prp20p and RCC1 share similar Ran GTPase binding mode.
      Title: The 1.9Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones.
    2. Report interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome.
      Title: Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome.
    3. Nup2p and the Ran guanylyl-nucleotide exchange factor, Prp20p, interact at specific chromatin regions and enable the NPC to play an active role in chromatin organization by facilitating the transition of chromatin between activity states.
      Title: The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ran guanyl-nucleotide exchange factor
    NP_011418.1
    • Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      321782..323230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180962.1 → NP_011418.1  TPA: Ran guanyl-nucleotide exchange factor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU48, P21827
      UniProtKB/TrEMBL
      A6ZU83, B3LHG2, B5VIM9, C7GW22, C8Z8F1, G2WE02, N1P1U3
      Conserved Domains (1) summary
      COG5184
      Location:15 → 477
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21827.1

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