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    SUA5 threonylcarbamoyladenylate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852707, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SUA5
    Official Full Name
    threonylcarbamoyladenylate synthase
    Primary source
    SGD:S000003137
    Locus tag
    YGL169W
    See related
    AllianceGenome:SGD:S000003137; FungiDB:YGL169W; VEuPathDB:YGL169W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-threonylcarbamoyladenylate synthase and single-stranded telomeric DNA binding activity. Involved in regulation of translational fidelity; tRNA threonylcarbamoyladenosine modification; and telomere maintenance. Located in mitochondrion. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SUA5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (186059..187339)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Spo74p Neighboring gene tRNA-Lys Neighboring gene Hur1p Neighboring gene Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Neighboring gene Cup2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae. Klima R, et al. Yeast, 1996 Sep. PMID 8896267
    2. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast. Pollo-Oliveira L, et al. Biomolecules, 2020 Feb 18. PMID 32085421, Free PMC Article
    3. Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes. Thiaville PC, et al. Eukaryot Cell, 2014 Sep. PMID 25038083, Free PMC Article
    4. In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. Perrochia L, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23258706, Free PMC Article
    5. Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Hampsey M, et al. Biochimie, 1991 Dec. PMID 1666843

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
      Title: Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
    2. Our results firmly established that Qri7p and Sua5p constitute the mitochondrial pathway for the biosynthesis of t(6)A and bring additional advancement in our understanding of the reaction mechanism
      Title: Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
    3. Sua5p is involved in the telomeric DNA recombination in telomerase-negative cells.
      Title: Sua5p is required for telomere recombination in Saccharomyces cerevisiae.
    4. A critical role for Sua5 and the t(6)A(37) modification in translational fidelity is revealed.
      Title: The Sua5 protein is essential for normal translational regulation in yeast.
    5. Deletion of SUA5 gene led to the loss of threonylcarbamoyladenosine.
      Title: The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.
    6. Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo.
      Title: Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-threonylcarbamoyladenylate synthase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-threonylcarbamoyladenylate synthase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    threonylcarbamoyladenylate synthase
    NP_011346.1
    • Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      186059..187339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181034.1 → NP_011346.1  TPA: threonylcarbamoyladenylate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTY3, P32579
      UniProtKB/TrEMBL
      B5VIF9
      Conserved Domains (2) summary
      COG0009
      Location:44 → 263
      SUA5; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]
      pfam03481
      Location:253 → 420
      SUA5; Putative GTP-binding controlling metal-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32579.1

    Gene LinkOut

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