TRA1 histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: TRA1
Official Full Name: histone acetyltransferase TRA1
Primary source: SGD:S000001141
Locus tag: YHR099W
See related: AllianceGenome:SGD:S000001141; FungiDB:YHR099W; VEuPathDB:YHR099W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to histone acetyltransferase activity. Involved in DNA repair; histone acetylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuA4 histone acetyltransferase complex; SAGA complex; and SLIK (SAGA-like) complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See TRA1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (302761..313995)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tra1 controls the transcriptional landscape of the aging cell.
Title: Tra1 controls the transcriptional landscape of the aging cell.
Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Title: Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Tra1 contributes to the overall integrity of NuA4, whereas, within SAGA, it specifically controls the incorporation of the de-ubiquitination module (DUB), as part of an ordered assembly pathway.
Title: Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Tra1 allows a single activator to recruit both SAGA and NuA4, and functions as a passive bridge between activators and coactivators. [review]
Title: Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.
The molecular structure of the SAGA and NuA4 coactivator subunit Tra1 has been reported.
Title: Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution.
Tra1 recruitment at Gcn4-dependent and Rap1-dependent promoters requires the same regions of Tra1, and separate regions of Tra1 contribute to the HAT activity and stability of the SAGA and NuA4 HAT modules.
Title: Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.
findings demonstrate the importance of the FATC domain in the structure/function of Tra1
Title: Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.
Genetic interactions have been identified which link Tra1 protein to gene expression, mitochondrial function, and membrane sorting/protein trafficking.
Title: Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SLIK (SAGA-like) complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: histone acetyltransferase TRA1

NP_011967.1

Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

302761..313995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179229.1 → NP_011967.1 TPA: histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011967.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL49, P38811

UniProtKB/TrEMBL

A6ZT07, C7GLY6, N1P137

Conserved Domains (1) summary

COG5032
Location:1232 → 3744

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]