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    VMA6 H(+)-transporting V0 sector ATPase subunit d [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851168, updated on 7-Jul-2024

    Summary

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    Gene symbol
    VMA6
    Gene description
    H(+)-transporting V0 sector ATPase subunit d
    Primary source
    FungiDB:YLR447C
    Locus tag
    YLR447C
    See related
    SGD:S000004439; AllianceGenome:SGD:S000004439; VEuPathDB:YLR447C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar transport. Located in fungal-type vacuole membrane. Orthologous to several human genes including ATP6V0D1 (ATPase H+ transporting V0 subunit d1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VMA6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1026856..1027893, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gmc2p Neighboring gene hexokinase Neighboring gene ribosomal 60S subunit protein L6B Neighboring gene peptidylprolyl isomerase FPR4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G(1-59)) of the Saccharomyces cerevisiae V(1)V(O) ATPase. Rishikesan S, et al. Biochim Biophys Acta, 2009 Apr. PMID 19344662
    2. The boxing glove shape of subunit d of the yeast V-ATPase in solution and the importance of disulfide formation for folding of this protein. Thaker YR, et al. J Bioenerg Biomembr, 2007 Aug. PMID 17896169
    3. Identification of a domain in the V0 subunit d that is critical for coupling of the yeast vacuolar proton-translocating ATPase. Owegi MA, et al. J Biol Chem, 2006 Oct 6. PMID 16891312
    4. Association of the eukaryotic V1VO ATPase subunits a with d and d with A. Thaker YR, et al. FEBS Lett, 2009 Apr 2. PMID 19289121
    5. VMA13 encodes a 54-kDa vacuolar H(+)-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiae. Ho MN, et al. J Biol Chem, 1993 Aug 25. PMID 8349704

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solution NMR of the recombinant N- (G(1-59)) and C-terminal segment (G(61-114)) of subunit G, has been performed in the absence and presence of subunit d of the yeast V-ATPase.
      Title: Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G(1-59)) of the Saccharomyces cerevisiae V(1)V(O) ATPase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-transporting V0 sector ATPase subunit d
    NP_013552.3
    • Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1026856..1027893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182335.3 → NP_013552.3  TPA: H(+)-transporting V0 sector ATPase subunit d [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013552.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ81, P32366
      UniProtKB/TrEMBL
      A0A6A5PX09, A7A1W6, B3RHV5, B5VNY4, C7GSK9, C8ZE54, G2WJQ8, N1NZY4
      Conserved Domains (1) summary
      COG1527
      Location:1 → 345
      NtpC; Archaeal/vacuolar-type H+-ATPase subunit C/Vma6 [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32366.2

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