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    VTH2 signal sequence-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853233, updated on 29-Jun-2024

    Summary

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    Gene symbol
    VTH2
    Gene description
    signal sequence-binding protein
    Primary source
    FungiDB:YJL222W
    Locus tag
    YJL222W
    See related
    SGD:S000003758; AllianceGenome:SGD:S000003758; VEuPathDB:YJL222W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signal sequence binding activity. Involved in Golgi to vacuole transport and protein targeting to vacuole. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORT1 (sortilin 1) and SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VTH2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (11475..16124)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Y' element ATP-dependent helicase Neighboring gene seripauperin PAU1 Neighboring gene oligo-1,6-glucosidase IMA4 Neighboring gene hexose transporter HXT9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. Cooper AA, et al. J Cell Biol, 1996 May. PMID 8636229, Free PMC Article
    2. Multiple pathways for vacuolar sorting of yeast proteinase A. Westphal V, et al. J Biol Chem, 1996 May 17. PMID 8662642
    3. Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. Coelho MC, et al. Nature, 2019 Feb. PMID 30700905, Free PMC Article
    4. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Ranjitkar P, et al. Mol Cell, 2010 Nov 12. PMID 21070971, Free PMC Article
    5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal sequence binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables signal sequence binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal sequence-binding protein
    NP_012313.1
    • Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      11475..16124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181655.1 → NP_012313.1  TPA: signal sequence-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8ZAZ9, D6VVX5, P40890
      UniProtKB/TrEMBL
      A0A8H4C0I3
      Conserved Domains (1) summary
      smart00602
      Location:728 → 1355
      VPS10; VPS10 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40890.1

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