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    UBX3 Ubx3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851467, updated on 7-Jul-2024

    Summary

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    Gene symbol
    UBX3
    Gene description
    Ubx3p
    Primary source
    FungiDB:YDL091C
    Locus tag
    YDL091C
    See related
    SGD:S000002249; AllianceGenome:SGD:S000002249; VEuPathDB:YDL091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables clathrin binding activity. Involved in clathrin-dependent endocytosis and histone H2B ubiquitination. Located in clathrin-coated vesicle. Part of Dsc E3 ubiquitin ligase complex. Orthologous to several human genes including FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UBX3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (293392..294759, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 Neighboring gene RNA-binding signal recognition particle subunit SRP14 Neighboring gene protein farnesyltransferase Neighboring gene Nur1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames. Boskovic J, et al. Yeast, 1996 Oct. PMID 8923743
    2. New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy. Farrell KB, et al. Genetics, 2015 Nov. PMID 26362318, Free PMC Article
    3. The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Bonizec M, et al. Nucleic Acids Res, 2014. PMID 25183520, Free PMC Article
    4. The UBX domain: a widespread ubiquitin-like module. Buchberger A, et al. J Mol Biol, 2001 Mar 16. PMID 11243799
    5. Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system. Yang X, et al. Elife, 2018 Jan 22. PMID 29355480, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a component of the clathrin-mediated endocytosis machinery
      Title: New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubx3p
    NP_010192.1
    • Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      293392..294759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180150.1 → NP_010192.1  TPA: Ubx3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRQ7, Q12229
      UniProtKB/TrEMBL
      A0A6A5PZ25, A6ZXN6, B3LGY6, B5VFH6, C7GJM3, C8Z6L2, N1P5Y4
      Conserved Domains (3) summary
      smart00594
      Location:151 → 274
      UAS; UAS domain
      pfam17380
      Location:271 → 360
      DUF5401; Family of unknown function (DUF5401)
      pfam00789
      Location:357 → 452
      UBX; UBX domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12229.1

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