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    BUG1 Bug1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851459, updated on 17-May-2024

    Summary

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    Gene symbol
    BUG1
    Gene description
    Bug1p
    Primary source
    FungiDB:YDL099W
    Locus tag
    YDL099W
    See related
    SGD:S000002257; AllianceGenome:SGD:S000002257; VEuPathDB:YDL099W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein secretion. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BUG1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (283419..284444)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase DUN1 Neighboring gene guanine nucleotide exchange factor GET3 Neighboring gene U4/U6-U5 snRNP complex subunit SNU23 Neighboring gene proteasome regulatory particle lid subunit RPN6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. Bruns C, et al. J Cell Biol, 2011 Dec 12. PMID 22144692, Free PMC Article
    2. The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic. Behnia R, et al. J Cell Biol, 2007 Jan 29. PMID 17261844, Free PMC Article
    3. Unconventional secretion of Acb1 is mediated by autophagosomes. Duran JM, et al. J Cell Biol, 2010 Feb 22. PMID 20156967, Free PMC Article
    4. Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays. Lu KY, et al. Mol Cell Proteomics, 2012 Nov. PMID 22843995, Free PMC Article
    5. Prion formation and polyglutamine aggregation are controlled by two classes of genes. Manogaran AL, et al. PLoS Genet, 2011 May. PMID 21625618, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bug1p
    NP_010184.1
    • Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      283419..284444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180158.1 → NP_010184.1  TPA: Bug1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRQ1, Q12191
      UniProtKB/TrEMBL
      A0A8H8UMJ1
      Conserved Domains (1) summary
      COG3883
      Location:191 → 272
      CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12191.1

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