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    NNF2 Nnf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852980, updated on 9-Jun-2024

    Summary

    Gene symbol
    NNF2
    Gene description
    Nnf2p
    Primary source
    FungiDB:YGR089W
    Locus tag
    YGR089W
    See related
    SGD:S000003321; AllianceGenome:SGD:S000003321; VEuPathDB:YGR089W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See NNF2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (656960..659770)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene indolepyruvate decarboxylase 6 Neighboring gene catalase T Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Nnf2p
    NP_011603.1
    • Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      656960..659770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181218.1NP_011603.1  TPA: Nnf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM1, P53253
      UniProtKB/TrEMBL
      A0A8H4C0H6, B5VJ33
      Conserved Domains (1) summary
      COG1196
      Location:818932
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]