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    GTF1 glutamyl-tRNA(Gln) amidotransferase subunit F [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852994, updated on 9-Jun-2024

    Summary

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    Gene symbol
    GTF1
    Gene description
    glutamyl-tRNA(Gln) amidotransferase subunit F
    Primary source
    FungiDB:YGR102C
    Locus tag
    YGR102C
    See related
    SGD:S000003334; AllianceGenome:SGD:S000003334; VEuPathDB:YGR102C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GTF1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (694584..695135, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein MDR1 Neighboring gene rhomboid protease PCP1 Neighboring gene mRNA-binding ribosome synthesis protein NOP7 Neighboring gene Srb5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transposon mutagenesis reveals novel loci affecting tolerance to salt stress and growth at low temperature. de Jesus Ferreira MC, et al. Curr Genet, 2001 Aug. PMID 11570514
    2. Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p. Moda BS, et al. Curr Genet, 2016 Aug. PMID 26780366
    3. Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases. Araiso Y, et al. Nucleic Acids Res, 2014 May. PMID 24692665, Free PMC Article
    4. Her2p molecular modeling, mutant analysis and intramitochondrial localization. Ferreira-Júnior JR, et al. Fungal Genet Biol, 2013 Nov. PMID 23850602
    5. Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase. Barros MH, et al. J Biol Chem, 2011 Sep 23. PMID 21799017, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of yeast mitochondrial GatFAB complex.
      Title: Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit F
    NP_011616.3
    • Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      694584..695135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181231.3 → NP_011616.3  TPA: glutamyl-tRNA(Gln) amidotransferase subunit F [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011616.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUN4, P53260, Q6Q591
      UniProtKB/TrEMBL
      A0A8H4C1S5, A6ZV84, B3LIC4, B5VJ49, C7GWW1, C8Z8Z5, G2WEI7
      Conserved Domains (1) summary
      cd21422
      Location:32 → 160
      GatF; mitochondrial glutamyl-tRNA(Gln) amidotransferase subunit F
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53260.1

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