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    EFM1 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856346, updated on 17-May-2024

    Summary

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    Gene symbol
    EFM1
    Gene description
    protein-lysine N-methyltransferase
    Primary source
    FungiDB:YHL039W
    Locus tag
    YHL039W
    See related
    SGD:S000001031; AllianceGenome:SGD:S000001031; VEuPathDB:YHL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation. Located in cytoplasm. Orthologous to human SETD3 (SET domain containing 3, actin histidine methyltransferase) and SETD4 (SET domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EFM1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (21783..23540)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene siderophore transporter Neighboring gene Cbp2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MT-MAMS: Protein Methyltransferase Motif Analysis by Mass Spectrometry. Hamey JJ, et al. J Proteome Res, 2018 Oct 5. PMID 30156103
    2. Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Li Z, et al. Virology, 2014 Jan 5. PMID 24314635
    3. Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Lipson RS, et al. Arch Biochem Biophys, 2010 Aug 15. PMID 20510667, Free PMC Article
    4. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. Porras-Yakushi TR, et al. J Biol Chem, 2006 Nov 24. PMID 17005568
    5. Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Couttas TA, et al. Proteomics, 2012 Apr. PMID 22522802

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine monomethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine monomethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-lysine N-methyltransferase
    NP_011824.1
    • Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      21783..23540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179119.1 → NP_011824.1  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT0, P38732
      UniProtKB/TrEMBL
      A0A8H4C135, A6ZSL2, B3LS82, C7GRT4, C8ZA24, N1P9K3
      Conserved Domains (1) summary
      cd19180
      Location:11 → 295
      SET_SpSET10-like; SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38732.1

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