U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NNT1 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850991, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NNT1
    Official Full Name
    S-adenosylmethionine-dependent methyltransferase
    Primary source
    SGD:S000004275
    Locus tag
    YLR285W
    See related
    AllianceGenome:SGD:S000004275; FungiDB:YLR285W; VEuPathDB:YLR285W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EFM7
    Summary
    Enables N-terminal protein N-methyltransferase activity and protein-lysine N-methyltransferase activity. Involved in rDNA heterochromatin formation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NNT1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (707360..708145)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Put7p Neighboring gene dodecenoyl-CoA isomerase Neighboring gene uncharacterized protein Neighboring gene chitinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Anderson RM, et al. Nature, 2003 May 8. PMID 12736687, Free PMC Article
    2. Calorie restriction extends yeast life span by lowering the level of NADH. Lin SJ, et al. Genes Dev, 2004 Jan 1. PMID 14724176, Free PMC Article
    3. Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A. White JT, et al. Biochemistry, 2019 Dec 10. PMID 31738538, Free PMC Article
    4. Characterization of Protein Methyltransferases Rkm1, Rkm4, Efm4, Efm7, Set5 and Hmt1 Reveals Extensive Post-Translational Modification. Winter DL, et al. J Mol Biol, 2018 Jan 5. PMID 29183786
    5. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. Wlodarski T, et al. PLoS One, 2011. PMID 21858014, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the methylation of lysine (Lys) in elongation factor 1A (eEF1A) by methyltransferase is conserved from yeast to human.
      Title: Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-terminal protein N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine dimethylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    S-adenosylmethionine-dependent methyltransferase
    NP_013387.1
    • S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      707360..708145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182172.1 → NP_013387.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYS9, Q05874
      UniProtKB/TrEMBL
      A7A1G6, C7GVS8, G2WJA7, N1NYI4
      Conserved Domains (1) summary
      COG3897
      Location:1 → 256
      Nnt1; Predicted nicotinamide N-methyase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05874.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools