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    IES2 Ies2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855506, updated on 17-May-2024

    Summary

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    Gene symbol
    IES2
    Gene description
    Ies2p
    Primary source
    FungiDB:YNL215W
    Locus tag
    YNL215W
    See related
    SGD:S000005159; AllianceGenome:SGD:S000005159; VEuPathDB:YNL215W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Located in nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IES2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (244468..245430)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative serine/threonine-protein phosphatase Neighboring gene DNA-binding transcription factor RAP1 Neighboring gene Pex17p Neighboring gene Rrg9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dosage of chromatin proteins affects transcriptional silencing and DNA repair in Saccharomyces cerevisiae. Benbow SZ, et al. FEBS Lett, 2008 Feb 20. PMID 18211810
    2. DNA repair defects ascribed to pby1 are caused by disruption of Holliday junction resolvase Mus81-Mms4. Ölmezer G, et al. DNA Repair (Amst), 2015 Sep. PMID 26068713
    3. Disruption and basic phenotypic analysis of 18 novel genes from the yeast Saccharomyces cerevisiae. Wysocki R, et al. Yeast, 1999 Jan 30. PMID 10029995
    4. The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Chambers AL, et al. Genes Dev, 2012 Dec 1. PMID 23207916, Free PMC Article
    5. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ies2p
    NP_014184.1
    • Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      244468..245430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183053.1 → NP_014184.1  TPA: Ies2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0X5, P40154
      UniProtKB/TrEMBL
      A0A6A5Q5B4, A6ZRM5, B3LP59, B5VQJ7, C7GPE2, G2WLP8, N1NZ65
      Conserved Domains (1) summary
      pfam04795
      Location:237 → 297
      PAPA-1; PAPA-1-like conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40154.1

    Gene LinkOut

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