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    NTO1 Nto1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856143, updated on 17-May-2024

    Summary

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    Gene symbol
    NTO1
    Gene description
    Nto1p
    Primary source
    FungiDB:YPR031W
    Locus tag
    YPR031W
    See related
    SGD:S000006235; AllianceGenome:SGD:S000006235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methylated histone binding activity. Involved in histone acetylation. Located in cytoplasm and nucleus. Part of NuA3a histone acetyltransferase complex and NuA3b histone acetyltransferase complex. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to several human genes including BRPF1 (bromodomain and PHD finger containing 1); BRPF3 (bromodomain and PHD finger containing 3); and BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NTO1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (631515..633761)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Apl4p Neighboring gene Csr2p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene histidine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Taverna SD, et al. Mol Cell, 2006 Dec 8. PMID 17157260, Free PMC Article
    2. H3 k36 methylation helps determine the timing of cdc45 association with replication origins. Pryde F, et al. PLoS One, 2009 Jun 12. PMID 19521516, Free PMC Article
    3. Mapping the local protein interactome of the NuA3 histone acetyltransferase. Smart SK, et al. Protein Sci, 2009 Sep. PMID 19621382, Free PMC Article
    4. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics. Kim JH, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33010166, Free PMC Article
    5. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Shi X, et al. J Biol Chem, 2007 Jan 26. PMID 17142463, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA3 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3a histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3b histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nto1p
    NP_015356.1
    • Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      631515..633761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184128.1 → NP_015356.1  TPA: Nto1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W441, Q12311
      UniProtKB/TrEMBL
      A0A8H4BUD1, B3LL92, B5VTI8, C7GQA7, C8ZJ55, N1P216
      Conserved Domains (1) summary
      COG5141
      Location:18 → 748
      COG5141; PHD zinc finger-containing protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12311.1

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