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    TIP41 Tip41p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856153, updated on 17-May-2024

    Summary

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    Gene symbol
    TIP41
    Gene description
    Tip41p
    Primary source
    FungiDB:YPR040W
    Locus tag
    YPR040W
    See related
    SGD:S000006244; AllianceGenome:SGD:S000006244; VEuPathDB:YPR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within negative regulation of TORC1 signaling. Located in cytoplasm and nucleus. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TIP41 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (647305..648375)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spo24p Neighboring gene flavin-linked sulfhydryl oxidase Neighboring gene Irc16p Neighboring gene translation initiation factor eIF5 Neighboring gene Puf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions of TIP41 and PBP1 Counteract These Effects. Park SK, et al. Viruses, 2022 Oct 15. PMID 36298819, Free PMC Article
    2. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Araki T, et al. Genes Genet Syst, 2005 Oct. PMID 16394584
    3. TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae. Shin CS, et al. J Cell Sci, 2009 Jun 15. PMID 19494127
    4. Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1. González A, et al. Mol Cell Biol, 2009 May. PMID 19273591, Free PMC Article
    5. Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Yorimitsu T, et al. Autophagy, 2009 Jul. PMID 19223769, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tip41p
    NP_015365.1
    • Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      647305..648375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184137.1 → NP_015365.1  TPA: Tip41p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W449, Q12199
      UniProtKB/TrEMBL
      A0A6A5Q5S7, A6ZWT2, B3LLA0, C7GQ99, C8ZJ65, G2WPL7, N1NVJ8
      Conserved Domains (1) summary
      pfam04176
      Location:130 → 312
      TIP41; TIP41-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12199.1

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