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    YPT53 Rab family GTPase YPT53 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855631, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YPT53
    Official Full Name
    Rab family GTPase YPT53
    Primary source
    SGD:S000005037
    Locus tag
    YNL093W
    See related
    AllianceGenome:SGD:S000005037; FungiDB:YNL093W; VEuPathDB:YNL093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in Golgi to endosome transport; endocytosis; and protein targeting to vacuole. Located in late endosome. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YPT53 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (449868..450530)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phosphatidate phosphatase APP1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nst1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity. Nakatsukasa K, et al. J Biol Chem, 2014 Jul 25. PMID 24923442, Free PMC Article
    2. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. Singer-Krüger B, et al. J Cell Biol, 1994 Apr. PMID 8163546, Free PMC Article
    3. Ordering of compartments in the yeast endocytic pathway. Prescianotto-Baschong C, et al. Traffic, 2002 Jan. PMID 11872141
    4. Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking. Pawelec A, et al. Eukaryot Cell, 2010 Apr. PMID 20173035, Free PMC Article
    5. Expression, purification, and biochemical properties of Ypt/Rab GTPase-activating proteins of Gyp family. Will E, et al. Methods Enzymol, 2001. PMID 11210571

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. when cells are exposed to nutrient stress for an extended period of time, the up-regulated Ypt53 and the constitutive Vps21 function redundantly to maintain these activities.
      Title: The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity.
    2. Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
      Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab family GTPase YPT53
    NP_014306.3
    • Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      449868..450530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182931.3 → NP_014306.3  TPA: Rab family GTPase YPT53 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014306.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W187, P36019, Q45TZ5
      UniProtKB/TrEMBL
      A6ZRY8, B3LNV1, B5VQV0, C8ZGD8, G2WM12, N1NWK8
      Conserved Domains (1) summary
      cd01860
      Location:12 → 180
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36019.1

    Gene LinkOut

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