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    ZNF525 zinc finger protein 525 [ Homo sapiens (human) ]

    Gene ID: 170958, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF525provided by HGNC
    Official Full Name
    zinc finger protein 525provided by HGNC
    Primary source
    HGNC:HGNC:29423
    See related
    Ensembl:ENSG00000203326 AllianceGenome:HGNC:29423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.8), prostate (RPKM 2.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF525 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53365705..53386590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56445220..56466092)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53868958..53889843)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 6, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53836118-53836982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15065 Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
    2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF765-ZNF761

    Readthrough gene: ZNF765-ZNF761, Included gene: ZNF765, Included gene: ZNF761

    Homology

    Clone Names

    • KIAA1979

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 525

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348156.2 → NP_001335085.1  zinc finger protein 525 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976
      Consensus CDS
      CCDS86802.1
      UniProtKB/Swiss-Prot
      J3KR51, Q8N782, Q8TF23
      Related
      ENSP00000417696.1, ENST00000474037.6
      Conserved Domains (3) summary
      COG5048
      Location:130 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    2. NM_001348157.2 → NP_001335086.1  zinc finger protein 525 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC010467, AC125388, BQ028675, DA790976, DB221179
      Consensus CDS
      CCDS86803.1
      UniProtKB/TrEMBL
      J3KR62
      Related
      ENSP00000419136.1, ENST00000467003.1
      Conserved Domains (5) summary
      COG5048
      Location:94 → 357
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:231 → 282
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:277 → 302
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 12
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RNA

    1. NR_145445.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976

    2. NR_145446.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5'exon, alternate internal exon, and uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC010467, AC125388, AK097037, BQ028675

    3. NR_145447.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC125388, AK097037, BQ028675, DA790976
      Related
      ENST00000475179.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53365705..53386590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56445220..56466092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N782.3 GenPept UniProtKB/Swiss-Prot:Q8N782

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials