NPBWR2 neuropeptides B and W receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPBWR2provided by HGNC
Official Full Name: neuropeptides B and W receptor 2provided by HGNC
Primary source: HGNC:HGNC:4530
See related: Ensembl:ENSG00000125522 MIM:600731; AllianceGenome:HGNC:4530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR8
Summary: The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (64103802..64107565, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65925944..65929663, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (62735155..62738918, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mainly expressed in brain or pituitary
Title: Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.
Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex.
Title: G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor
Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
distribution in central nervous system and peripheral tissues with precursor peptides
Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481713

RH70583 (e-PCR)
- UniSTS:84658

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: neuropeptides B/W receptor type 2

Names: G-protein coupled receptor 8; neuropeptides B/W receptor 2; opioid-somatostatin-like receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005286.4 → NP_005277.2 neuropeptides B/W receptor type 2

See identical proteins and their annotated locations for NP_005277.2

Status: REVIEWED

Source sequence(s)

AL121581

Consensus CDS

CCDS13557.1

UniProtKB/Swiss-Prot

P48146, Q6NWQ6, Q9H4K3

UniProtKB/TrEMBL

Q6NWQ5

Related

ENSP00000508236.1, ENST00000684052.1

Conserved Domains (1) summary

cd15087
Location:46 → 327

7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors