U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CBP3 Cbp3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855886, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CBP3
    Official Full Name
    Cbp3p
    Primary source
    SGD:S000006136
    Locus tag
    YPL215W
    See related
    AllianceGenome:SGD:S000006136; FungiDB:YPL215W; VEuPathDB:YPL215W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity and ribosome binding activity. Involved in mitochondrial respiratory chain complex III assembly and positive regulation of mitochondrial translation. Located in mitochondrial membrane and mitochondrial ribosome. Part of Cbp3p-Cbp6 complex. Orthologous to human UQCC1 (ubiquinol-cytochrome c reductase complex assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CBP3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (147416..148423)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene GTPase BMS1 Neighboring gene uncharacterized protein Neighboring gene bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase Neighboring gene U2 snRNP complex subunit LEA1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria. Heinemeyer J, et al. J Biol Chem, 2007 Apr 20. PMID 17322303
    2. Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1) complex assembly in Saccharomyces cerevisiae. Kronekova Z, et al. Curr Genet, 2005 Apr. PMID 15759116
    3. Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly. Ndi M, et al. J Biol Chem, 2019 Nov 8. PMID 31537648, Free PMC Article
    4. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, et al. J Cell Biol, 2011 Jun 13. PMID 21670217, Free PMC Article
    5. Cbp3 and Cbp6 are dispensable for synthesis regulation of cytochrome b in yeast mitochondria. García-Guerrero AE, et al. J Biol Chem, 2018 Apr 13. PMID 29475949, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate that the essential role of Cbp3 and Cbp6 is to assist Cytb hemylation and demonstrate that in the absence of heme b, Cytb can form non-functional supercomplexes with cytochrome c oxidase.
      Title: Cbp3 and Cbp6 are dispensable for synthesis regulation of cytochrome b in yeast mitochondria.
    2. Cbp3-Cbp6 also coordinates cytochrome b synthesis with bc(1) complex assembly
      Title: The Cbp3-Cbp6 complex coordinates cytochrome b synthesis with bc(1) complex assembly in yeast mitochondria.
    3. Results suggest that synthesis of cytochrome b occurs preferentially on those ribosomes that have the Cbp3-Cbp6 complex bound to their tunnel exit, an arrangement that may ensure tight coordination of cytochrome b synthesis and assembly.
      Title: Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly.
    4. Cbp3p and Cbp4p are two mitochondrial proteins which are postulated to act as chaperones in bc(1) complex formation.
      Title: Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1) complex assembly in Saccharomyces cerevisiae.
    5. model of the cytochrome C reductase/oxidase supercomplex from Saccharomyces mitochondria
      Title: A structural model of the cytochrome C reductase/oxidase supercomplex from yeast mitochondria.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cbp3p-Cbp6 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cbp3p
    NP_015109.1
    • Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      147416..148423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184029.1 → NP_015109.1  TPA: Cbp3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3F5, P21560
      UniProtKB/TrEMBL
      A6ZW40, B3LKL5, C7GN42, C8ZIG4, G2WNX0, N1NXY3
      Conserved Domains (1) summary
      pfam03981
      Location:146 → 286
      Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21560.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools