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    VHS1 putative serine/threonine protein kinase VHS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851834, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VHS1
    Official Full Name
    putative serine/threonine protein kinase VHS1
    Primary source
    SGD:S000002655
    Locus tag
    YDR247W
    See related
    AllianceGenome:SGD:S000002655; FungiDB:YDR247W; VEuPathDB:YDR247W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; and regulation of protein localization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VHS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (956013..957398)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene TRAPP subunit TRS23 Neighboring gene uncharacterized protein Neighboring gene gluconokinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study. Marullo P, et al. BMC Genomics, 2019 Aug 28. PMID 31462217, Free PMC Article
    2. Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast. Hepowit NL, et al. Elife, 2020 Oct 19. PMID 33074099, Free PMC Article
    3. Analysis of yeast protein kinases using protein chips. Zhu H, et al. Nat Genet, 2000 Nov. PMID 11062466
    4. The Std1 Activator of the Snf1/AMPK Kinase Controls Glucose Response in Yeast by a Regulated Protein Aggregation. Simpson-Lavy K, et al. Mol Cell, 2017 Dec 21. PMID 29249654
    5. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Muñoz I, et al. Yeast, 2003 Jan 30. PMID 12518319

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase VHS1
    NP_010533.1
    • Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      956013..957398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180555.1 → NP_010533.1  TPA: putative serine/threonine protein kinase VHS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010533.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03785
      UniProtKB/TrEMBL
      B3LG41, B5VGD3, C7GTI3, C8Z5F9, N1P6N9
      Conserved Domains (1) summary
      cd13993
      Location:11 → 330
      STKc_Pat1_like; Catalytic domain of Fungal Pat1-like Serine/Threonine kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03785.1

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