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    SRX1 sulfiredoxin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853776, updated on 17-May-2024

    Summary

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    Gene symbol
    SRX1
    Gene description
    sulfiredoxin
    Primary source
    FungiDB:YKL086W
    Locus tag
    YKL086W
    See related
    SGD:S000001569; AllianceGenome:SGD:S000001569; VEuPathDB:YKL086W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sulfiredoxin activity. Involved in cellular response to oxidative stress. Located in cytoplasm and nucleus. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRX1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (278281..278664)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene cytochrome c1 heme lyase CYT2 Neighboring gene malate dehydrogenase MDH1 Neighboring gene Hot13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo. Boukhenouna S, et al. Antioxid Redox Signal, 2015 Mar 20. PMID 25387359, Free PMC Article
    2. Probing the mechanism of the peroxiredoxin decamer interaction with its reductase sulfiredoxin from the single molecule to the solution scale. Beaussart A, et al. Nanoscale Horiz, 2022 May 3. PMID 35234779
    3. Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin. Moon JC, et al. Biochem Biophys Res Commun, 2013 Mar 8. PMID 23396059
    4. Molecular and functional characterization of sulfiredoxin homologs from higher plants. Liu XP, et al. Cell Res, 2006 Mar. PMID 16541127
    5. Catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide sulfiredoxin intermediate that is reduced by thioredoxin. Roussel X, et al. J Biol Chem, 2009 Nov 27. PMID 19801666, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study provides both in vitro and in vivo evidence of the role of GSH as the primary reducer of 1-Cys Srxs.
      Title: Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo.
    2. these findings suggest that Srx1 regulates YPrx1 function and structure in yeast cells through a direct interaction.
      Title: Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin.
    3. These data collectively emphasize the significance of sulfiredoxin, peroxiredoxin, and mitochondrial respiratory chain to respond to and to protect from 100% O(2).
      Title: Significance of sulfiredoxin/peroxiredoxin and mitochondrial respiratory chain in response to and protection from 100% O(2) in Saccharomyces cerevisiae.
    4. Results show that an oxidized sulfiredoxin under disulfide state is formed between the catalytic Cys(84) and Cys(48), and this oxidized is reduced selectively by thioredoxin.
      Title: Catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide sulfiredoxin intermediate that is reduced by thioredoxin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfiredoxin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfiredoxin
    NP_012837.1
    • Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      278281..278664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179652.1 → NP_012837.1  TPA: sulfiredoxin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXK2, P36077
      UniProtKB/TrEMBL
      A0A6A5PU79, A6ZZN2, B3LR06, C7GVM4, C8ZC88, G2WHU7, N1P067
      Conserved Domains (1) summary
      COG5119
      Location:1 → 127
      COG5119; Uncharacterized protein, contains ParB-like nuclease domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36077.1

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