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    ESBP6 Esbp6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855598, updated on 17-May-2024

    Summary

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    Gene symbol
    ESBP6
    Gene description
    Esbp6p
    Primary source
    FungiDB:YNL125C
    Locus tag
    YNL125C
    See related
    SGD:S000005069; AllianceGenome:SGD:S000005069; VEuPathDB:YNL125C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCH3
    Summary
    Predicted to enable symporter activity. Predicted to be involved in transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome; cataract 47; familial hyperinsulinemic hypoglycemia 7; and intellectual disability. Orthologous to several human genes including SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ESBP6 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (390146..392167, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Far11p Neighboring gene Spc98p Neighboring gene RNA-binding snoRNP assembly protein Neighboring gene Nma111p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of ESBP6 improves lactic acid resistance and production in Saccharomyces cerevisiae. Sugiyama M, et al. J Biosci Bioeng, 2016 Oct. PMID 27102264
    2. Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution. Pereira R, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33106428, Free PMC Article
    3. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
    4. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Stefely JA, et al. Nat Biotechnol, 2016 Nov. PMID 27669165, Free PMC Article
    5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Esbp6p
    NP_014274.1
    • Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      390146..392167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182963.1 → NP_014274.1  TPA: Esbp6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W158, P53918
      UniProtKB/TrEMBL
      A0A8H4BWJ8, A6ZRV9, G2WLY2
      Conserved Domains (1) summary
      cd17352
      Location:212 → 606
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53918.1

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