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    SDS24 Sds24p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852515, updated on 17-May-2024

    Summary

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    Gene symbol
    SDS24
    Gene description
    Sds24p
    Primary source
    FungiDB:YBR214W
    Locus tag
    YBR214W
    See related
    SGD:S000000418; AllianceGenome:SGD:S000000418; VEuPathDB:YBR214W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including AMP binding activity; protein kinase binding activity; and protein serine/threonine phosphatase inhibitor activity. Involved in endocytosis and septum digestion after cytokinesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SDS24 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (651415..652998)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ngr1p Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Hpc2p Neighboring gene Ybp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional conservation between fission yeast moc1/sds23 and its two orthologs, budding yeast SDS23 and SDS24, and phenotypic differences in their disruptants. Goldar MM, et al. Biosci Biotechnol Biochem, 2005 Jul. PMID 16041152
    2. Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae. Hood-DeGrenier JK. Yeast, 2011 Mar. PMID 21360731
    3. SAC3 may link nuclear protein export to cell cycle progression. Jones AL, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716708, Free PMC Article
    4. Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Wiederkehr A, et al. Yeast, 2001 Jun. PMID 11378903
    5. Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA. Akdoğan E, et al. PLoS One, 2016. PMID 26751567, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septum digestion after cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Sds24p
    NP_009773.1
    • Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      651415..652998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178562.1 → NP_009773.1  TPA: Sds24p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZLF4, D6VQL0, P38314
      UniProtKB/TrEMBL
      A0A8H4BTB0, B3LMU6, B5VEG5, D3UEW0, G2W9L7, N1P8P5
      Conserved Domains (3) summary
      COG0517
      Location:114 → 247
      CBS; CBS domain [Signal transduction mechanisms]
      cd02205
      Location:203 → 279
      CBS_pair_SF; CBS repeat [structural motif]
      cl15354
      Location:203 → 331
      CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38314.1

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