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    ARO9 aromatic-amino-acid:2-oxoglutarate transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856539, updated on 2-Nov-2024

    Summary

    Official Symbol
    ARO9
    Official Full Name
    aromatic-amino-acid:2-oxoglutarate transaminase
    Primary source
    SGD:S000001179
    Locus tag
    YHR137W
    See related
    AllianceGenome:SGD:S000001179; FungiDB:YHR137W; VEuPathDB:YHR137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aromatic-amino-acid transaminase activity. Involved in L-phenylalanine biosynthetic process and tyrosine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ARO9 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (375709..377250)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase YCK1 Neighboring gene Spl2p Neighboring gene uncharacterized protein Neighboring gene Sps100p Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-aminoadipate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-phenylalanine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aromatic-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aromatic-amino-acid transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aromatic-amino-acid transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables kynurenine-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-phenylalanine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aromatic amino acid family catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aromatic amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tyrosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tyrosine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    aromatic-amino-acid:2-oxoglutarate transaminase
    NP_012005.1
    • Aromatic aminotransferase II; involved in tyrosine, phenylalanine, and methionine metabolism; involved with Aro8p in production of kynurenic acid to detoxify excess tryptophan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      375709..377250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179267.1NP_012005.1  TPA: aromatic-amino-acid:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012005.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL86, P38840, P87291
      UniProtKB/TrEMBL
      B3LSQ1, N1P167
      Conserved Domains (1) summary
      COG1167
      Location:11508
      ARO8; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]