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    PRY3 Pry3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853367, updated on 17-May-2024

    Summary

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    Gene symbol
    PRY3
    Gene description
    Pry3p
    Primary source
    FungiDB:YJL078C
    Locus tag
    YJL078C
    See related
    SGD:S000003614; AllianceGenome:SGD:S000003614; VEuPathDB:YJL078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in fatty acid transport and sterol transport. Located in fungal-type cell wall. Orthologous to human GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRY3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (291336..293981, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Scp160p Neighboring gene sterol-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ics3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the transcription activator Ste12p as a repressor of PRY3 expression. Bickel KS, et al. Mol Cell Biol, 2006 Nov. PMID 16940175, Free PMC Article
    2. The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain. Cottier S, et al. Biol Open, 2020 Jul 2. PMID 32554483, Free PMC Article
    3. Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Choudhary V, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027975, Free PMC Article
    4. The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein. Darwiche R, et al. J Biol Chem, 2017 May 19. PMID 28365570, Free PMC Article
    5. The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders. Law GL, et al. Genome Biol, 2005. PMID 16420678, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pry3p
    NP_012457.1
    • GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      291336..293981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181511.1 → NP_012457.1  TPA: Pry3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWA5, P47033
      UniProtKB/TrEMBL
      A0A8H4C024, B3LQ34, N1NZU2
      Conserved Domains (2) summary
      cd05384
      Location:24 → 152
      CAP_PRY1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins
      NF033849
      Location:598 → 855
      ser_rich_anae_1; serine-rich protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47033.1

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