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    AIM46 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856606, updated on 22-Aug-2024

    Summary

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    Official Symbol
    AIM46
    Primary source
    FungiDB:YHR199C
    Locus tag
    YHR199C
    See related
    SGD:S000001242; AllianceGenome:SGD:S000001242; VEuPathDB:YHR199C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP34
    Summary
    Predicted to enable intramolecular lyase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (497490..498422, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rix1p Neighboring gene Aim18p Neighboring gene borealin Neighboring gene proteasome regulatory particle base subunit RPN10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae. Schmitz JM, et al. J Biol Chem, 2023 Mar. PMID 36739946, Free PMC Article
    2. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Alkhaja AK, et al. Mol Biol Cell, 2012 Jan. PMID 22114354, Free PMC Article
    3. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast. Ghosh C, et al. Sci Signal, 2021 May 25. PMID 34035143, Free PMC Article
    4. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article
    5. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
      Title: Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intramolecular lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aim46p
    NP_012069.3
    • Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      497490..498422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179330.3 → NP_012069.3  TPA: Aim46p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012069.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTA5, B3LSV9, B5VKC8, C7GRM1, C8Z9Z9, D3DLE7, P38885
      UniProtKB/TrEMBL
      G2WFS2, N1P315
      Conserved Domains (1) summary
      pfam16035
      Location:97 → 303
      Chalcone_2; Chalcone isomerase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38885.1

    Gene LinkOut

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