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    GLYATL2 glycine-N-acyltransferase like 2 [ Homo sapiens (human) ]

    Gene ID: 219970, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GLYATL2provided by HGNC
    Official Full Name
    glycine-N-acyltransferase like 2provided by HGNC
    Primary source
    HGNC:HGNC:24178
    See related
    Ensembl:ENSG00000156689 MIM:614762; AllianceGenome:HGNC:24178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GATF-B; BXMAS2-10
    Summary
    Enables glycine N-acyltransferase activity. Involved in long-chain fatty acid catabolic process; medium-chain fatty acid catabolic process; and monounsaturated fatty acid catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in gall bladder (RPKM 3.1), salivary gland (RPKM 1.2) and 5 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GLYATL2 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58834065..58909828, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58783586..58859330, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58601538..58612177, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase pseudogene Neighboring gene MPRA-validated peak1282 silencer Neighboring gene Sharpr-MPRA regulatory region 12556 Neighboring gene translation machinery associated 16 homolog pseudogene 1 Neighboring gene glycine-N-acyltransferase like 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:58672857-58673356 Neighboring gene glycine-N-acyltransferase like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:58694840-58695354 Neighboring gene uncharacterized LOC283194 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene glycine-N-acyltransferase like 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. Waluk DP, et al. J Biol Chem, 2012 May 11. PMID 22408254, Free PMC Article
    2. Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. Waluk DP, et al. FASEB J, 2010 Aug. PMID 20305126
    3. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. acetylation of lysine(s) in hGLYATL2 regulates the enzyme activity, thus linking post-translational modification of proteins with the production of biological signaling molecules, the N-acyl glycines.
      Title: Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules.
    2. report on the characterization of human glycine N-acyltransferase-like 2 (hGLYATL2) and show that it synthesizes various N-acyl glycines.
      Title: Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC24009

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-chain fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in medium-chain fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monounsaturated fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine N-acyltransferase-like protein 2
    Names
    acyl-CoA:glycine N-acyltransferase-like protein 2
    glycine acyltransferase family-B
    NP_659453.3
    XP_016872826.1
    XP_016872827.1
    XP_047282501.1
    XP_054223967.1
    XP_054223968.1
    XP_054223969.1
    XP_054223970.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145016.4 → NP_659453.3  glycine N-acyltransferase-like protein 2

      See identical proteins and their annotated locations for NP_659453.3

      Status: VALIDATED

      Source sequence(s)
      AP001652, AW264415, BC021682
      Consensus CDS
      CCDS41649.1
      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2
      Related
      ENSP00000287275.1, ENST00000287275.6
      Conserved Domains (2) summary
      pfam08444
      Location:202 → 290
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:10 → 199
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      58834065..58909828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017338.3 → XP_016872827.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2
      Conserved Domains (2) summary
      pfam08444
      Location:202 → 290
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:10 → 199
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    2. XM_047426545.1 → XP_047282501.1  glycine N-acyltransferase-like protein 2 isoform X2

    3. XM_017017337.3 → XP_016872826.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2
      Related
      ENSP00000434277.1, ENST00000532258.1
      Conserved Domains (2) summary
      pfam08444
      Location:202 → 290
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:10 → 199
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      58783586..58859330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367995.1 → XP_054223970.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2

    2. XM_054367993.1 → XP_054223968.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2

    3. XM_054367992.1 → XP_054223967.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2

    4. XM_054367994.1 → XP_054223969.1  glycine N-acyltransferase-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A5LGC7, Q86WC3, Q8WU03, Q96AT2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WU03.1 GenPept UniProtKB/Swiss-Prot:Q8WU03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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