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    LINC01270 long intergenic non-protein coding RNA 1270 [ Homo sapiens (human) ]

    Gene ID: 284751, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC01270provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1270provided by HGNC
    Primary source
    HGNC:HGNC:27658
    See related
    Ensembl:ENSG00000203999 AllianceGenome:HGNC:27658
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in liver (RPKM 1.2), appendix (RPKM 1.0) and 21 other tissues See more
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    Genomic context

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    See LINC01270 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50292720..50314919)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52062422..52084536)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48909257..48931456)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372656 Neighboring gene MPRA-validated peak4248 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891163-48891664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891665-48892164 Neighboring gene plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48894009-48894546 Neighboring gene Sharpr-MPRA regulatory region 10045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48908810-48909546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48910660-48911160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48921517-48922292 Neighboring gene Sharpr-MPRA regulatory region 5066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925071-48925582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925583-48926093 Neighboring gene long intergenic non-protein coding RNA 1271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48937461-48938045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938046-48938631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938632-48939216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18086 Neighboring gene uncharacterized LOC105372657 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48971862-48972074 Neighboring gene MPRA-validated peak4249 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:48990074-48990574 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48995605-48996033 Neighboring gene uncharacterized LOC124904928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Abnormal expression of long non‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs. Liu Y, et al. Acta Neurobiol Exp (Wars), 2024 Mar 28. PMID 38587325
    2. Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway. Li S, et al. Cell Biol Toxicol, 2023 Aug. PMID 36241925
    3. Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation. Li N, et al. Cancer Gene Ther, 2021 May. PMID 33199829
    4. Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326. Zhang W, et al. Bioengineered, 2022 Jun. PMID 36694453, Free PMC Article
    5. LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Jiang B, et al. Bioengineered, 2022 Apr. PMID 35345980, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abnormal expression of long non-coding RNA LINC01270 in glioma and its correlation with X-ray computed tomography signs.
      Title: Abnormal expression of long non‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs.
    2. Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway.
      Title: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway.
    3. Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
      Title: Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
    4. LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.
      Title: LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.
    5. Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation.
      Title: Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034124.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      AK090605, AL354889
      Related
      ENST00000371639.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      50292720..50314919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      52062422..52084536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025463.1: Suppressed sequence

      Description
      NM_001025463.1: This RefSeq was permanently suppressed because it contains repetitive sequence, is a nonsense-mediated mRNA decay (NMD) candidate and currently there is insufficient support for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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