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    ICS3 Ics3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853368, updated on 17-May-2024

    Summary

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    Gene symbol
    ICS3
    Gene description
    Ics3p
    Primary source
    FungiDB:YJL077C
    Locus tag
    YJL077C
    See related
    SGD:S000003613; AllianceGenome:SGD:S000003613; VEuPathDB:YJL077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in copper ion homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ICS3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (294666..295061, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Pry3p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Net1p Neighboring gene Apq13p Neighboring gene cohesin subunit SMC3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene ICS3 from the yeast Saccharomyces cerevisiae is involved in copper homeostasis dependent on extracellular pH. Alesso CA, et al. Fungal Genet Biol, 2015 Sep. PMID 26127016
    2. Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. Norambuena L, et al. BMC Chem Biol, 2008 Jan 7. PMID 18179719, Free PMC Article
    3. Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Copic A, et al. Genetics, 2009 Jul. PMID 19433630, Free PMC Article
    4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
    5. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Scherrer T, et al. Genome Biol, 2011. PMID 21232131, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ics3p
    NP_012458.1
    • Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      294666..295061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181510.1 → NP_012458.1  TPA: Ics3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWA7, P47034
      UniProtKB/TrEMBL
      A0A8H4F918, B3LQ36, C7GR37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47034.1

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