JEM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: JEM1
Primary source: FungiDB:YJL073W
Locus tag: YJL073W
See related: SGD:S000003609; AllianceGenome:SGD:S000003609; VEuPathDB:YJL073W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KAR8
Summary: Enables chaperone binding activity and unfolded protein binding activity. Involved in karyogamy involved in conjugation with cellular fusion; protein folding in endoplasmic reticulum; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Jem1p facilitates nuclear inner-membrane fusion and spindle pole body (SPB) fusion
Title: Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IGI Inferred from Genetic Interaction more info	PubMed
enables unfolded protein binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in karyogamy involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding in endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane-endoplasmic reticulum membrane network	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012462.3

DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2

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The following sections contain reference sequences that belong to a specific genome build. Explain