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    ISA1 Fe-binding Fe/S cluster assembly protein ISA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850632, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ISA1
    Official Full Name
    Fe-binding Fe/S cluster assembly protein ISA1
    Primary source
    SGD:S000003950
    Locus tag
    YLL027W
    See related
    AllianceGenome:SGD:S000003950; FungiDB:YLL027W; VEuPathDB:YLL027W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables iron ion binding activity. Involved in biotin biosynthetic process; iron-sulfur cluster assembly; and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ISA1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (87403..88155)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene aminopeptidase P Neighboring gene polyamine transporter TPO1 Neighboring gene chaperone ATPase HSP104 Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins. Pelzer W, et al. FEBS Lett, 2000 Jul 7. PMID 10913600
    2. The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae. Mühlenhoff U, et al. Eukaryot Cell, 2007 Mar. PMID 17259550, Free PMC Article
    3. Isa1p is a component of the mitochondrial machinery for maturation of cellular iron-sulfur proteins and requires conserved cysteine residues for function. Kaut A, et al. J Biol Chem, 2000 May 26. PMID 10748136
    4. Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. Mühlenhoff U, et al. J Biol Chem, 2011 Dec 2. PMID 21987576, Free PMC Article
    5. hIscA: a protein implicated in the biogenesis of iron-sulfur clusters. Cózar-Castellano I, et al. Biochim Biophys Acta, 2004 Aug 2. PMID 15262227

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fe-binding Fe/S cluster assembly protein ISA1
    NP_013073.1
    • Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      87403..88155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181847.1 → NP_013073.1  TPA: Fe-binding Fe/S cluster assembly protein ISA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXX7, Q07821
      UniProtKB/TrEMBL
      A7A0N0, B3LTE3, C8ZCU5, G2WIG8, N1P1I0
      Conserved Domains (1) summary
      TIGR00049
      Location:148 → 250
      TIGR00049; Iron-sulfur cluster assembly accessory protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07821.1

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