TRPV2 transient receptor potential cation channel subfamily V member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRPV2provided by HGNC
Official Full Name: transient receptor potential cation channel subfamily V member 2provided by HGNC
Primary source: HGNC:HGNC:18082
See related: Ensembl:ENSG00000187688 MIM:606676; AllianceGenome:HGNC:18082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VRL; VRL1; VRL-1
Summary: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (16415571..16437003)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (16317872..16339304)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (16318885..16340317)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
Title: Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity.
Title: TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity.
TCAF1 promotes TRPV2-mediated Ca[2+] release in response to cytosolic DNA to protect stressed replication forks.
Title: TCAF1 promotes TRPV2-mediated Ca(2+) release in response to cytosolic DNA to protect stressed replication forks.
TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
Title: TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
Ion channel TRPV2 is critical in enhancing B cell activation and function.
Title: Ion channel TRPV2 is critical in enhancing B cell activation and function.
Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer.
Title: Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer.
TRPV2, a novel player in the human ovary and human granulosa cells.
Title: TRPV2, a novel player in the human ovary and human granulosa cells.
The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
Title: The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.
Title: Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.
Impact of the TRPV2 Inhibitor on Advanced Heart Failure in Patients with Muscular Dystrophy: Exploratory Study of Biomarkers Related to the Efficacy of Tranilast.
Title: Impact of the TRPV2 Inhibitor on Advanced Heart Failure in Patients with Muscular Dystrophy: Exploratory Study of Biomarkers Related to the Efficacy of Tranilast.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transient receptor potential cation channel V, member 2 (TRPV2) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	TAS Traceable Author Statement more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables monoatomic ion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	TAS Traceable Author Statement more info
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 2

Names: OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016113.5 → NP_057197.2 transient receptor potential cation channel subfamily V member 2

See identical proteins and their annotated locations for NP_057197.2

Status: REVIEWED

Source sequence(s)

AK289705, BC018926

Consensus CDS

CCDS32576.1

UniProtKB/Swiss-Prot

A6NML2, A8K0Z0, Q9Y5S1, Q9Y670

Related

ENSP00000342222.7, ENST00000338560.12

Conserved Domains (3) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 764

trp; transient-receptor-potential calcium channel protein

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

16415571..16437003

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006721541.5 → XP_006721604.1 transient receptor potential cation channel subfamily V member 2 isoform X2

Conserved Domains (3) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 732

trp; transient-receptor-potential calcium channel protein

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_011523922.3 → XP_011522224.1 transient receptor potential cation channel subfamily V member 2 isoform X3

Conserved Domains (3) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 705

trp; transient-receptor-potential calcium channel protein

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_006721543.5 → XP_006721606.1 transient receptor potential cation channel subfamily V member 2 isoform X5

See identical proteins and their annotated locations for XP_006721606.1

Conserved Domains (5) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:452 → 652

Ion_trans; Ion transport protein

pfam12796
Location:114 → 192

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:163 → 229

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_047436217.1 → XP_047292173.1 transient receptor potential cation channel subfamily V member 2 isoform X5
XM_005256677.3 → XP_005256734.1 transient receptor potential cation channel subfamily V member 2 isoform X7

See identical proteins and their annotated locations for XP_005256734.1

Conserved Domains (3) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 630

trp; transient-receptor-potential calcium channel protein

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_017024732.3 → XP_016880221.1 transient receptor potential cation channel subfamily V member 2 isoform X9
XM_005256676.3 → XP_005256733.1 transient receptor potential cation channel subfamily V member 2 isoform X1

See identical proteins and their annotated locations for XP_005256733.1

Conserved Domains (3) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 763

trp; transient-receptor-potential calcium channel protein

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_047436216.1 → XP_047292172.1 transient receptor potential cation channel subfamily V member 2 isoform X4
XM_017024730.3 → XP_016880219.1 transient receptor potential cation channel subfamily V member 2 isoform X6
XM_017024731.3 → XP_016880220.1 transient receptor potential cation channel subfamily V member 2 isoform X8
XM_011523923.3 → XP_011522225.1 transient receptor potential cation channel subfamily V member 2 isoform X12

Conserved Domains (4) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:114 → 192

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:163 → 229

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_047436219.1 → XP_047292175.1 transient receptor potential cation channel subfamily V member 2 isoform X11
XM_005256678.6 → XP_005256735.1 transient receptor potential cation channel subfamily V member 2 isoform X10

Conserved Domains (4) summary

cd00204
Location:163 → 314

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:114 → 192

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:163 → 229

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:162 → 193

ANK; ANK repeat [structural motif]
XM_047436220.1 → XP_047292176.1 transient receptor potential cation channel subfamily V member 2 isoform X13
XM_011523925.3 → XP_011522227.1 transient receptor potential cation channel subfamily V member 2 isoform X14

UniProtKB/TrEMBL

B3KMH7

Conserved Domains (1) summary

pfam00520
Location:22 → 222

Ion_trans; Ion transport protein

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

16317872..16339304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316379.1 → XP_054172354.1 transient receptor potential cation channel subfamily V member 2 isoform X2
XM_054316380.1 → XP_054172355.1 transient receptor potential cation channel subfamily V member 2 isoform X3
XM_054316383.1 → XP_054172358.1 transient receptor potential cation channel subfamily V member 2 isoform X5
XM_054316382.1 → XP_054172357.1 transient receptor potential cation channel subfamily V member 2 isoform X5
XM_054316385.1 → XP_054172360.1 transient receptor potential cation channel subfamily V member 2 isoform X7
XM_054316387.1 → XP_054172362.1 transient receptor potential cation channel subfamily V member 2 isoform X9
XM_054316378.1 → XP_054172353.1 transient receptor potential cation channel subfamily V member 2 isoform X1
XM_054316381.1 → XP_054172356.1 transient receptor potential cation channel subfamily V member 2 isoform X4
XM_054316384.1 → XP_054172359.1 transient receptor potential cation channel subfamily V member 2 isoform X6
XM_054316386.1 → XP_054172361.1 transient receptor potential cation channel subfamily V member 2 isoform X8
XM_054316390.1 → XP_054172365.1 transient receptor potential cation channel subfamily V member 2 isoform X12
XM_054316389.1 → XP_054172364.1 transient receptor potential cation channel subfamily V member 2 isoform X11
XM_054316388.1 → XP_054172363.1 transient receptor potential cation channel subfamily V member 2 isoform X10
XM_054316391.1 → XP_054172366.1 transient receptor potential cation channel subfamily V member 2 isoform X13
XM_054316392.1 → XP_054172367.1 transient receptor potential cation channel subfamily V member 2 isoform X14