ANAPC11 anaphase promoting complex subunit 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANAPC11provided by HGNC
Official Full Name: anaphase promoting complex subunit 11provided by HGNC
Primary source: HGNC:HGNC:14452
See related: Ensembl:ENSG00000141552 MIM:614534; AllianceGenome:HGNC:14452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APC11; Apc11p; HSPC214
Summary: Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81890790..81900533)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82757952..82767693)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79848666..79858409)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.
Title: The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer.
Overexpression of APC11 is correlated with chromosomal instability in colorectal cancer. An association is observed between APC11 expression and lymphovascular invasion and residual tumor. High levels of APC11 protein in primary colorectal tumors is specifically correlated with metastasis at diagnosis.
Title: Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.
siRNA targeted against Apc11 could hamper entry into G2/M phase.
Title: Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase.
The authors showed, in vitro, a direct interaction between Orf virus anaphase promoting complex regulator and APC2 and its interference with interactions between APC11 and APC2.
Title: Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.
Studies indicate that APC/C(Cdh1) is required to maintain genomic stability.
Title: The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.
APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
Title: APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
Inhibition of APC11 function by H(2)O(2) contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress
Title: The RING-H2-finger protein APC11 as a target of hydrogen peroxide.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A006A06 (e-PCR)
- UniSTS:13081

RH16023 (e-PCR)
- UniSTS:24152

RH65274 (e-PCR)
- UniSTS:45027

D17S1466E (e-PCR)
- UniSTS:150506

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-ubiquitin ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in anaphase-promoting complex-dependent catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic metaphase/anaphase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K11-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein branched polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of meiotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IDA Inferred from Direct Assay more info	PubMed
part_of anaphase-promoting complex	IPI Inferred from Physical Interaction more info	PubMed
part_of anaphase-promoting complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anaphase-promoting complex subunit 11

Names: APC11 anaphase promoting complex subunit 11 homolog; anaphase promoting complex subunit 11 (yeast APC11 homolog); cyclosome subunit 11; hepatocellular carcinoma-associated RING finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002244.2 → NP_001002244.1 anaphase-promoting complex subunit 11 isoform 1

See identical proteins and their annotated locations for NP_001002244.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK308091, BC000607, HY067392

Consensus CDS

CCDS32769.1

Related

ENSP00000349957.3, ENST00000357385.7

Conserved Domains (1) summary

cl17238
Location:1 → 51

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001002245.2 → NP_001002245.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001002245.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AK308091, BC000607, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000461648.2, ENST00000571024.6

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001002246.2 → NP_001002246.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001002246.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AF151048, AK308091, BC000607, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000460064.2, ENST00000574924.6

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001002247.2 → NP_001002247.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001002247.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AK308091, BC000607, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000463640.1, ENST00000579978.5

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001002248.3 → NP_001002248.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001002248.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AF151048, AK308091, BC000607, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000339695.5, ENST00000344877.10

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001002249.2 → NP_001002249.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001002249.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AK308091, BC066308, BM845909

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000376181.3, ENST00000392376.7

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001289414.1 → NP_001276343.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001276343.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AA356010, AK308091, AW965775

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000458143.1, ENST00000571570.5

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001289415.1 → NP_001276344.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001276344.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AK308091, BC171898, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000458265.2, ENST00000572851.6

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001289416.1 → NP_001276345.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001276345.1

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks an exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AK308091, BC066308, BM845909, BY796995

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000463598.1, ENST00000583839.1

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001289417.1 → NP_001276346.1 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_001276346.1

Status: VALIDATED

Description

Transcript Variant: This variant (11) uses an alternate splice site and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AC145207, AK308091, CA335305, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000464615.1, ENST00000578550.5

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001289420.1 → NP_001276349.1 anaphase-promoting complex subunit 11 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (14) lacks an exon and contains two alternate exons in the 5' UTR, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC145207, AK308091, BC066308, BM762129, BM845909

UniProtKB/Swiss-Prot

Q9NYG5

Conserved Domains (2) summary

pfam12678
Location:2 → 37

zf-rbx1; RING-H2 zinc finger

cl17238
Location:1 → 51

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_016476.11 → NP_057560.8 anaphase-promoting complex subunit 11 isoform 2

See identical proteins and their annotated locations for NP_057560.8

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.

Source sequence(s)

AF151048, AK308091, BC000607, BF512771, HY067392

Consensus CDS

CCDS11789.1

UniProtKB/Swiss-Prot

A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2

Related

ENSP00000459200.2, ENST00000571874.6

Conserved Domains (1) summary

cl17238
Location:1 → 84

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81890790..81900533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

82757952..82767693

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001289418.1: Suppressed sequence

Description

NM_001289418.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
NM_001289419.1: Suppressed sequence

Description

NM_001289419.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.