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    ZNF610 zinc finger protein 610 [ Homo sapiens (human) ]

    Gene ID: 162963, updated on 1-Jul-2024

    Summary

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    Official Symbol
    ZNF610provided by HGNC
    Official Full Name
    zinc finger protein 610provided by HGNC
    Primary source
    HGNC:HGNC:26687
    See related
    Ensembl:ENSG00000167554 AllianceGenome:HGNC:26687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 6.2), ovary (RPKM 3.3) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF610 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52330221..52367778)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55416488..55455012)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52839496..52871031)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 766 Neighboring gene microRNA 643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15045 Neighboring gene zinc finger protein 480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52841280-52841780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15048 Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52900414-52901613 Neighboring gene zinc finger protein 528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma.
      Title: Silencing of ZNF610 suppresses cell proliferation and migration in lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36040, MGC102679, DKFZp547A1010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 610
    Names
    zink finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161425.2 → NP_001154897.1  zinc finger protein 610 isoform a

      See identical proteins and their annotated locations for NP_001154897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC010320, AK290888, BC039903, DA133752, DB577508
      Consensus CDS
      CCDS12851.1
      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
      Related
      ENSP00000383922.2, ENST00000403906.8
      Conserved Domains (6) summary
      smart00349
      Location:24 → 82
      KRAB; krueppel associated box
      COG5048
      Location:257 → 446
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:24 → 63
      KRAB; KRAB box
      pfam13465
      Location:274 → 297
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001161426.2 → NP_001154898.1  zinc finger protein 610 isoform a

      See identical proteins and their annotated locations for NP_001154898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC010320, BC105967, DA133752, DB577508
      Consensus CDS
      CCDS12851.1
      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
      Related
      ENSP00000324441.8, ENST00000321287.12
      Conserved Domains (6) summary
      smart00349
      Location:24 → 82
      KRAB; krueppel associated box
      COG5048
      Location:257 → 446
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:24 → 63
      KRAB; KRAB box
      pfam13465
      Location:274 → 297
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001161427.2 → NP_001154899.1  zinc finger protein 610 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. Isoform b is shorter than isoform a.
      Source sequence(s)
      AC010320, AK093359, BC039903, BC105967, DA133752, DB577508
      Consensus CDS
      CCDS54309.1
      UniProtKB/Swiss-Prot
      Q8N9Z0
      Related
      ENSP00000471021.1, ENST00000601151.5
      Conserved Domains (6) summary
      smart00349
      Location:24 → 64
      KRAB; krueppel associated box
      COG5048
      Location:214 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:217 → 239
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:24 → 63
      KRAB; KRAB box
      pfam13465
      Location:231 → 254
      zf-H2C2_2; Zinc-finger double domain

    4. NM_173530.3 → NP_775801.2  zinc finger protein 610 isoform a

      See identical proteins and their annotated locations for NP_775801.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC010320, AK093359, BC105967, DB577508
      Consensus CDS
      CCDS12851.1
      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
      Related
      ENSP00000327597.7, ENST00000327920.12
      Conserved Domains (6) summary
      smart00349
      Location:24 → 82
      KRAB; krueppel associated box
      COG5048
      Location:257 → 446
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:234 → 254
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:24 → 63
      KRAB; KRAB box
      pfam13465
      Location:274 → 297
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52330221..52367778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438286.1 → XP_047294242.1  zinc finger protein 610 isoform X1

      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

    2. XM_047438287.1 → XP_047294243.1  zinc finger protein 610 isoform X1

      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9
      Related
      ENSP00000485001.1, ENST00000616431.2

    3. XM_047438285.1 → XP_047294241.1  zinc finger protein 610 isoform X1

      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

    4. XM_047438284.1 → XP_047294240.1  zinc finger protein 610 isoform X1

      UniProtKB/Swiss-Prot
      A8K4C3, Q86YH8, Q8N9Z0, Q8NDS9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55416488..55455012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320025.1 → XP_054176000.1  zinc finger protein 610 isoform X1

    2. XM_054320026.1 → XP_054176001.1  zinc finger protein 610 isoform X1

    3. XM_054320024.1 → XP_054175999.1  zinc finger protein 610 isoform X1

    4. XM_054320023.1 → XP_054175998.1  zinc finger protein 610 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9Z0.2 GenPept UniProtKB/Swiss-Prot:Q8N9Z0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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