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    STPG1 sperm tail PG-rich repeat containing 1 [ Homo sapiens (human) ]

    Gene ID: 90529, updated on 14-Nov-2024

    Summary

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    Official Symbol
    STPG1provided by HGNC
    Official Full Name
    sperm tail PG-rich repeat containing 1provided by HGNC
    Primary source
    HGNC:HGNC:28070
    See related
    Ensembl:ENSG00000001460 MIM:615826; AllianceGenome:HGNC:28070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAPO2; C1orf201
    Summary
    Involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 15.3), brain (RPKM 3.3) and 20 other tissues See more
    Orthologs
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    Genomic context

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    See STPG1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24356999..24415044, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24195358..24254108, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24683489..24741534, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24581311-24581877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24604941-24605442 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24612590-24613188 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24613189-24613787 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24624394-24624641 Neighboring gene Sharpr-MPRA regulatory region 347 Neighboring gene GRHL3 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24648587-24649104 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:24649105-24649620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 432 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:24661406-24662028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24664014-24664642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24664643-24665269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24669049-24669863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 396 Neighboring gene grainyhead like transcription factor 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:24691307-24692506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 398 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24714266-24714492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 400 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:24745074-24746273 Neighboring gene NIPA like domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24782303-24782815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:24784099-24784600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 402 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24828715-24828887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 433 Neighboring gene MPRA-validated peak119 silencer Neighboring gene RCAN3 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24860519-24861170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24861821-24862472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24862473-24863122 Neighboring gene RCAN family member 3 Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPO2 gene product might positively contribute to the induction of apoptosis triggered by O-methylguanine
      Title: The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33340

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O(6)-methylguanine-induced apoptosis 2
    Names
    O6-methylguanine-induced apoptosis 2
    UPF0490 protein C1orf201
    sperm-tail PG-rich repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199012.2 → NP_001185941.1  O(6)-methylguanine-induced apoptosis 2 isoform 1

      See identical proteins and their annotated locations for NP_001185941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      BC040212, BC063891
      Consensus CDS
      CCDS55581.1
      UniProtKB/Swiss-Prot
      Q49AP0, Q5TH74, Q6P3R4, Q86VU9, Q8WVQ3
      Related
      ENSP00000363530.1, ENST00000374409.5

    2. NM_001199013.2 → NP_001185942.1  O(6)-methylguanine-induced apoptosis 2 isoform 1

      See identical proteins and their annotated locations for NP_001185942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      AL031431, BC047705, BC063891, BI917854, BM922375
      Consensus CDS
      CCDS55581.1
      UniProtKB/Swiss-Prot
      Q49AP0, Q5TH74, Q6P3R4, Q86VU9, Q8WVQ3
      Related
      ENSP00000337461.4, ENST00000337248.9

    3. NM_001199014.2 → NP_001185943.1  O(6)-methylguanine-induced apoptosis 2 isoform 3

      See identical proteins and their annotated locations for NP_001185943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 5' region, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL031431, BC035061, BC063891, BI917854
      UniProtKB/Swiss-Prot
      Q5TH74

    4. NM_178122.5 → NP_835223.1  O(6)-methylguanine-induced apoptosis 2 isoform 2

      See identical proteins and their annotated locations for NP_835223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the CDS compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL031431, BC047705, BI917854
      Consensus CDS
      CCDS253.1
      Related
      ENSP00000003583.8, ENST00000003583.12

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      24356999..24415044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542403.3 → XP_011540705.2  O(6)-methylguanine-induced apoptosis 2 isoform X1

    2. XM_047433681.1 → XP_047289637.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      24195358..24254108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339512.1 → XP_054195487.1  O(6)-methylguanine-induced apoptosis 2 isoform X2

    2. XM_054339513.1 → XP_054195488.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TH74.1 GenPept UniProtKB/Swiss-Prot:Q5TH74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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