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    VIPR2 vasoactive intestinal peptide receptor 2 [ Homo sapiens (human) ]

    Gene ID: 7434, updated on 14-Nov-2024

    Summary

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    Official Symbol
    VIPR2provided by HGNC
    Official Full Name
    vasoactive intestinal peptide receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:12695
    See related
    Ensembl:ENSG00000106018 MIM:601970; AllianceGenome:HGNC:12695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
    Summary
    This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in ovary (RPKM 1.9), brain (RPKM 1.9) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See VIPR2 in Genome Data Viewer
    Location:
    7q36.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (159028175..159144867, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (160254532..160371379, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158820866..158937559, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158768653-158769393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158806403-158807032 Neighboring gene LINC00689 intron CAGE-defined high expression enhancer Neighboring gene long intergenic non-protein coding RNA 689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158820859-158821787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158823906-158824558 Neighboring gene Sharpr-MPRA regulatory region 8832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158832214-158832714 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158850668-158851867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158876624-158877154 Neighboring gene VISTA enhancer hs1753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158905439-158906114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:158939357-158940556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158961997-158963196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158984505-158985004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18875 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:159035435-159035650 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 2850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites. Kalló I, et al. Eur J Neurosci, 2004 Apr. PMID 15090046
    2. Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. Wilmot B, et al. J Child Psychol Psychiatry, 2016 Feb. PMID 26304033, Free PMC Article
    3. Monocytes from Sjögren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis. Hauk V, et al. Clin Exp Immunol, 2014 Sep. PMID 24827637, Free PMC Article
    4. A competitive PCR assay confirms the association of a copy number variation in the VIPR2 gene with schizophrenia in Han Chinese. Yuan J, et al. Schizophr Res, 2014 Jun. PMID 24794882
    5. CD4+ T cells in HIV infection show increased levels of expression of a receptor for vasoactive intestinal peptide, VPAC2. Ipp H, et al. Immunol Res, 2014 Oct. PMID 24469917

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer.
      Title: VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer.
    2. Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
      Title: Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
    3. Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
      Title: Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
    4. TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
      Title: TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
    5. Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
      Title: Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
    6. PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
      Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
    7. AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
      Title: AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
    8. Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
      Title: Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
    9. Dysfunction of VIPR2 leads to myopia in humans and mice.
      Title: Dysfunction of VIPR2 leads to myopia in humans and mice.
    10. Association of VIPR2 and ZMAT4 with high myopia.
      Title: Association of VIPR2 and ZMAT4 with high myopia.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pituitary adenylate cyclase-activating polypeptide receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables vasoactive intestinal polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    vasoactive intestinal polypeptide receptor 2
    Names
    PACAP type III receptor
    VIP and PACAP receptor 2
    helodermin-preferring VIP receptor
    pituitary adenylate cyclase-activating polypeptide type III receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304522.2 → NP_001291451.1  vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001291451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC004863, AK131406, AK308955, KJ534961
      UniProtKB/TrEMBL
      X5DP12
      Conserved Domains (2) summary
      smart00008
      Location:52 → 118
      HormR; Domain present in hormone receptors
      cl21561
      Location:120 → 291
      7tm_4; Olfactory receptor

    2. NM_001308259.1 → NP_001295188.1  vasoactive intestinal polypeptide receptor 2 isoform 3

      See identical proteins and their annotated locations for NP_001295188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC004863, AK131406, CA449700
      Consensus CDS
      CCDS78295.1
      UniProtKB/Swiss-Prot
      P41587
      Related
      ENSP00000366860.3, ENST00000377633.7
      Conserved Domains (1) summary
      pfam00002
      Location:107 → 355
      7tm_2; 7 transmembrane receptor (Secretin family)

    3. NM_003382.5 → NP_003373.2  vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003373.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC004863, AC007269, AF027390, KC877184
      Consensus CDS
      CCDS5950.1
      UniProtKB/Swiss-Prot
      P41587, Q13053, Q15870, Q53Y09, Q6ZN22, Q9UCW0
      UniProtKB/TrEMBL
      X5D7Q6
      Related
      ENSP00000262178.2, ENST00000262178.7
      Conserved Domains (2) summary
      smart00008
      Location:52 → 118
      HormR; Domain present in hormone receptors
      cd15986
      Location:123 → 392
      7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_130758.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004863, AC007269, AF027390, KC877184

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      159028175..159144867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      160254532..160371379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41587.2 GenPept UniProtKB/Swiss-Prot:P41587

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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