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    DUSP28 dual specificity phosphatase 28 [ Homo sapiens (human) ]

    Gene ID: 285193, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DUSP28provided by HGNC
    Official Full Name
    dual specificity phosphatase 28provided by HGNC
    Primary source
    HGNC:HGNC:33237
    See related
    Ensembl:ENSG00000188542 AllianceGenome:HGNC:33237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VHP; DUSP26
    Summary
    Enables phosphatase activity. Involved in dephosphorylation. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 1.8), bone marrow (RPKM 1.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP28 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240560054..240565256)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241054084..241059286)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241499471..241504673)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723825 Neighboring gene NFE2L2 motif-containing MPRA enhancer 30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241338263-241338901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241339542-241340180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241351335-241351920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241366327-241366828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241366829-241367328 Neighboring gene Sharpr-MPRA regulatory region 14717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241374143-241374719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241376453-241377029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241377081-241377582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241394718-241395368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241397321-241397972 Neighboring gene glypican 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241397973-241398622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241398623-241399273 Neighboring gene GPC1 antisense RNA 1 Neighboring gene microRNA 149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241417613-241418122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241418123-241418632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241418633-241419142 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241439369-241439869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241443459-241443959 Neighboring gene Sharpr-MPRA regulatory region 11390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241467695-241468196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241494599-241495099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12515 Neighboring gene conserved acetylation island sequence C08 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241508348-241508986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241508987-241509625 Neighboring gene Sharpr-MPRA regulatory region 11586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17406 Neighboring gene arginyl aminopeptidase like 1 Neighboring gene CAPN10 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DUSP28 promotes cell proliferation, migration, and invasion by Akt/β-catenin/Slug axis in breast cancer. Zhang J, et al. Acta Biochim Pol, 2022 Dec 15. PMID 36520087
    2. Scattered DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine and paracrine signaling in metastatic pancreatic cancer. Lee J, et al. Cancer Lett, 2019 Aug 1. PMID 30902562
    3. Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. Ku B, et al. PLoS One, 2017. PMID 29121083, Free PMC Article
    4. Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells. Lee J, et al. Sci Rep, 2015 Jul 27. PMID 26212664, Free PMC Article
    5. Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A. Lee J, et al. Sci Rep, 2017 Oct 6. PMID 28986588, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUSP28 promotes cell proliferation, migration, and invasion by Akt/beta-catenin/Slug axis in breast cancer.
      Title: DUSP28 promotes cell proliferation, migration, and invasion by Akt/β-catenin/Slug axis in breast cancer.
    2. DUSP28 significantly increased the migration, invasion, and viability of metastatic pancreatic cancer cells through the activation of CREB, AKT, and ERK1/2 signaling pathways.
      Title: Scattered DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine and paracrine signaling in metastatic pancreatic cancer.
    3. These results establish novel insight into DUSP28 and PDGF-A related autonomous signaling pathway in pancreatic cancer.
      Title: Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A.
    4. Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28
      Title: Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28.
    5. Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer.
      Title: DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.
    6. Collectively, these results indicate that DUSP28 plays a key role in drug resistance and migratory activity in human pancreatic cells, and suggest that targeting DUSP28 might have clinical relevance in eradicating malignant pancreatic cancers.
      Title: Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells.
    7. Taken together, these data demonstrate that DUSP28 plays a significant role in HCC progression and may be a feasible molecular target for anti-cancer therapy.
      Title: DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity phosphatase 28
    NP_001028747.1
    NP_001357394.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033575.1 → NP_001028747.1  dual specificity phosphatase 28

      See identical proteins and their annotated locations for NP_001028747.1

      Status: VALIDATED

      Source sequence(s)
      AC124862, BC036198, BG656420, BQ777661
      Consensus CDS
      CCDS33418.1
      UniProtKB/Swiss-Prot
      Q4G0W2
      Related
      ENSP00000344235.2, ENST00000343217.6
      Conserved Domains (1) summary
      cd14574
      Location:19 → 158
      DUSP28; dual specificity protein phosphatase 28

    2. NM_001370465.2 → NP_001357394.1  dual specificity phosphatase 28

      Status: VALIDATED

      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS33418.1
      UniProtKB/Swiss-Prot
      Q4G0W2
      Related
      ENSP00000385885.2, ENST00000405954.2
      Conserved Domains (1) summary
      cd14574
      Location:19 → 158
      DUSP28; dual specificity protein phosphatase 28

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240560054..240565256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241054084..241059286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486346.1 RNA Sequence

    2. XR_008486347.1 RNA Sequence

    3. XR_008486348.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0W2.1 GenPept UniProtKB/Swiss-Prot:Q4G0W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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