TIM17 protein transporter TIM17 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TIM17
Official Full Name: protein transporter TIM17
Primary source: SGD:S000003679
Locus tag: YJL143W
See related: AllianceGenome:SGD:S000003679; FungiDB:YJL143W; VEuPathDB:YJL143W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MIM17; MPI2; SMS1
Summary: Contributes to protein transmembrane transporter activity. Involved in mitochondrial genome maintenance and protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A) and TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TIM17 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (147101..147577)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in TM1 and TM2 impaired the interaction of Tim17 with Tim23, component of the translocation channel, whereas mutations in TM3 compromised binding of the import motor. The authors identified residues in the matrix-facing region of Tim17 involved in binding of the import motor.
Title: Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.
Overexpression of TIM17 prevents the complete loss of mtDNA in cells lacking Abf2.
Title: The conserved translocase Tim17 prevents mitochondrial DNA loss.
charged residues in Tim17 are critical for the preprotein-induced gating of the TIM23 translocase
Title: Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria.
Tim17p is required for twin pore structure and provides the voltage gate for the TIM23 channel complex.
Title: Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to protein transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial genome maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein transporter TIM17

NP_012392.1

Essential core component of the TIM23 protein translocase complex; forms the protein translocation path with Mgr2p, while Tim23p contributes to the architecture of the import channel; may link the import motor to the core translocase of the inner mitochondrial membrane (TIM23 complex)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

147101..147577

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181576.1 → NP_012392.1 TPA: protein transporter TIM17 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012392.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW42, P39515, Q02310

UniProtKB/TrEMBL

A6ZQI7, B3LPX6, B5VL38, C7GPY8, C8ZB76, G2WGM8, N1P0G6

Conserved Domains (1) summary

TIGR00980
Location:2 → 158

3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17