YHB1 flavohemoglobin [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YHB1
Official Full Name: flavohemoglobin
Primary source: SGD:S000003466
Locus tag: YGR234W
See related: AllianceGenome:SGD:S000003466; FungiDB:YGR234W; VEuPathDB:YGR234W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YHB4
Summary: Enables nitric oxide reductase activity. Involved in cellular response to misfolded protein; cellular response to oxidative stress; and cellular response to reactive nitrogen species. Located in cytosol and mitochondrial matrix. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

multiple Puf proteins coordinately regulate YHB1 mRNA to protect cells from nitric oxide stress.
Title: Conditional regulation of Puf1p, Puf4p, and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric oxide stress in yeast.
The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as Gln1 and Kes1 as putative candidates for being evaluated as biomarkers for diagnostic assays of S. cerevisiae infections.
Title: Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model.
YHb functions in oxidative stress indirectly by consuming NO, which inhibits mitochondrial respiration and leads to enhanced production of reactive oxygen species
Title: Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide dioxygenase NAD(P)H activity	IBA Inferred from Biological aspect of Ancestor more info
enables nitric oxide dioxygenase NAD(P)H activity	IEA Inferred from Electronic Annotation more info
enables nitric oxide reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to chemical stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrosative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive nitrogen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_011750.1

Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain