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    TRM3 tRNA (guanosine(18)-2'-O)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851446, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRM3
    Official Full Name
    tRNA (guanosine(18)-2'-O)-methyltransferase
    Primary source
    SGD:S000002270
    Locus tag
    YDL112W
    See related
    AllianceGenome:SGD:S000002270; FungiDB:YDL112W; VEuPathDB:YDL112W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine) methyltransferase activity. Involved in cellular response to oxidative stress and tRNA nucleoside ribose methylation. Located in cytoplasm. Orthologous to human TARBP1 (TAR (HIV-1) RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TRM3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (258915..263225)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene short-chain dehydrogenase/reductase Neighboring gene Atg20p Neighboring gene exosome non-catalytic core subunit RRP42 Neighboring gene Tma17p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. Cavaillé J, et al. RNA, 1999 Jan. PMID 9917067, Free PMC Article
    2. 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. Endres L, et al. PLoS One, 2020. PMID 32053677, Free PMC Article
    3. Bootstrapping the interactome: unsupervised identification of protein complexes in yeast. Friedel CC, et al. J Comput Biol, 2009 Aug. PMID 19630542
    4. Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates. Balakirev MY, et al. Elife, 2015 Sep 8. PMID 26349035, Free PMC Article
    5. Cross-compartment signal propagation in the mitotic exit network. Zhou X, et al. Elife, 2021 Jan 22. PMID 33481703, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(18)-2'-O)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine) methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA nucleoside ribose methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanosine(18)-2'-O)-methyltransferase
    NP_010171.1
    • 2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      258915..263225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180171.1 → NP_010171.1  TPA: tRNA (guanosine(18)-2'-O)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRN8, P89896, Q05336, Q07527, Q7LGS3
      UniProtKB/TrEMBL
      B5VFF7, C7GJK4, N1PA91
      Conserved Domains (1) summary
      cd18091
      Location:1286 → 1431
      SpoU-like_TRM3-like; SAM-dependent tRNA methylase related to TRM3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07527.1

    Gene LinkOut

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