YRB1 Ran GTPase-binding protein YRB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: YRB1
Gene description: Ran GTPase-binding protein YRB1
Primary source: FungiDB:YDR002W
Locus tag: YDR002W
See related: SGD:S000002409; AllianceGenome:SGD:S000002409; VEuPathDB:YDR002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CST20; HTN1; SFO1; STP52
Summary: Enables small GTPase binding activity. Involved in G1/S transition of mitotic cell cycle; nucleocytoplasmic transport; and ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human RANBP1 (RAN binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YRB1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (453045..453650)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure shows that on association of Ran-binding domain (RanBD) of RanBP1 with CRM1:NES-cargo:RanGTP complex, RanBD and the C-terminal acidic tail of Ran induce a large movement of the intra-HEAT9 loop of CRM1.
Title: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ran GTPase-binding protein YRB1

NP_010285.1

Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

453045..453650

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180310.1 → NP_010285.1 TPA: Ran GTPase-binding protein YRB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010285.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRY9, P41920

UniProtKB/TrEMBL

A0A6A5PZB5, A6ZXW7, B3LGQ7, B5VFR2, C7GXY9, C8Z4S1, G2WCF5, N1P601

Conserved Domains (1) summary

COG5171
Location:1 → 201

YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]