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    KAP104 Kap104p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852305, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KAP104
    Official Full Name
    Kap104p
    Primary source
    SGD:S000000221
    Locus tag
    YBR017C
    See related
    AllianceGenome:SGD:S000000221; FungiDB:YBR017C; VEuPathDB:YBR017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nuclear localization sequence binding activity. Involved in exit from mitosis and protein import into nucleus. Located in cellular bud neck; cellular bud tip; and cytosol. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to several human genes including TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See KAP104 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (270947..273703, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase MNN2 Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1 Neighboring gene UDP-glucose:hexose-1-phosphate uridylyltransferase Neighboring gene ncRNA Neighboring gene bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and functional analysis of a 7.2 kb fragment of Saccharomyces cerevisiae chromosome II including GAL7 and GAL10 and a new essential open reading frame. Schaaff-Gerstenschläger I, et al. Yeast, 1995 Jan. PMID 7762304
    2. A karyopherin acts in localized protein synthesis. Veenhoff LM, et al. Cell Cycle, 2010 Apr 1. PMID 20305392
    3. Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. Truant R, et al. Mol Cell Biol, 1998 Mar. PMID 9488461, Free PMC Article
    4. A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1. Lange A, et al. J Biol Chem, 2008 May 9. PMID 18343812, Free PMC Article
    5. Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals. Süel KE, et al. PLoS Biol, 2008 Jun 3. PMID 18532879, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data hypothesize on a possible function of Kap104p in the localized protein synthesis.
      Title: A karyopherin acts in localized protein synthesis.
    2. Temporally and spatially coordinated localization of Kap104p is a new mechanism for the asymmetric distribution of protein synthesis in dividing cells.
      Title: Nuclear transport factor directs localization of protein synthesis during mitosis.
    3. identified three Proline-tyrosine nuclear localization signals regions that are important for binding Kap104p
      Title: Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals.
    4. The Kap104p supports import for nuclear uptake of H3 and H4.
      Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kap104p
    NP_009573.1
    • Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      270947..273703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178365.1 → NP_009573.1  TPA: Kap104p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009573.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ19, P38217
      UniProtKB/TrEMBL
      B3LNC4, B5VDY6, N1P7Y5
      Conserved Domains (3) summary
      pfam13513
      Location:435 → 489
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:424 → 528
      HEAT_2; HEAT repeats
      sd00044
      Location:422 → 450
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38217.1

    Gene LinkOut

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