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    ADH2 alcohol dehydrogenase ADH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855349, updated on 9-Jun-2024

    Summary

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    Gene symbol
    ADH2
    Gene description
    alcohol dehydrogenase ADH2
    Primary source
    FungiDB:YMR303C
    Locus tag
    YMR303C
    See related
    SGD:S000004918; AllianceGenome:SGD:S000004918; VEuPathDB:YMR303C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADR2
    Summary
    Enables alcohol dehydrogenase (NAD+) activity. Involved in NADH oxidation; amino acid catabolic process to alcohol via Ehrlich pathway; and ethanol metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADH2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (873291..874337, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1 Neighboring gene Yme2p Neighboring gene ubiquitin-specific protease UBP15 Neighboring gene putative family 17 glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved bioethanol production using CRISPR/Cas9 to disrupt the ADH2 gene in Saccharomyces cerevisiae. Xue T, et al. World J Microbiol Biotechnol, 2018 Oct 1. PMID 30276556
    2. Improvement of Ethanol Production in Saccharomyces cerevisiae by High-Efficient Disruption of the ADH2 Gene Using a Novel Recombinant TALEN Vector. Ye W, et al. Front Microbiol, 2016. PMID 27462304, Free PMC Article
    3. Use of the valine biosynthetic pathway to convert glucose into isobutanol. Savrasova EA, et al. J Ind Microbiol Biotechnol, 2011 Sep. PMID 21161324
    4. [Cloning, expression and evaluation of Saccharomyces cerevisiae ADH2]. Yu M, et al. Sheng Wu Gong Cheng Xue Bao, 2010 Feb. PMID 20432933
    5. Yeast alcohol dehydrogenase II. EBISUZAKI K, et al. Arch Biochem Biophys, 1957 Jul. PMID 13445227

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADH2 proved to have ethanol dehydrogenase activity.
      Title: [Cloning, expression and evaluation of Saccharomyces cerevisiae ADH2].
    2. ADH2 expression in the med14 mutant is stimulated by Adr1.
      Title: Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
    3. ADH2 expression was dependent on these factors with wild-type Adr1
      Title: Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.
    4. the absence of the Isw1 and Chd1 ATP-dependent chromatin remodelling activities delays the maximal expression of ADH2 without impairing the chromatin remodelling that occurs upon activation
      Title: The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization.
    5. analysis of Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae
      Title: Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables butanol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ethanol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alcohol dehydrogenase ADH2
    NP_014032.1
    • Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      873291..874337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182812.1 → NP_014032.1  TPA: alcohol dehydrogenase ADH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D0, P00331
      UniProtKB/TrEMBL
      A0A0B4VJL3, G2WL12
      Conserved Domains (1) summary
      cd08297
      Location:7 → 345
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00331.3

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