GAPCP-2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: GAPCP-2
Primary source: TAIR:AT1G16300
Locus tag: AT1G16300
See related: Araport:AT1G16300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F3O9.10; F3O9_10; glyceraldehyde-3-phosphate dehydrogenase of plastid 2
Summary: Encodes one of the chloroplast/plastid localized GAPDH isoforms (GAPCp1/At1g79530 and GAPCp2/At1g16300). gapcp double mutants display a drastic phenotype of arrested root development, dwarfism and sterility. GAPCps are important for the synthesis of serine in roots.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Results indicate that the main function of gapcp2 is to supply 3-PGA for anabolic pathways in plastids of heterotrophic cells and suggest that the plastidial glycolysis may contribute to fatty acid biosynthesis in seeds.
Title: Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants.
Mutants deficient in plastidial gapcp1 and gapcp2 are abscisic acid insensitive in growth.
Title: Arabidopsis plants deficient in plastidial glyceraldehyde-3-phosphate dehydrogenase show alterations in abscisic acid (ABA) signal transduction: interaction between ABA and primary metabolism.
Two Arabidopsis thaliana chloroplast/plastid-localized GAPDH isoforms (GAPCp1 and GAPCp2), were identified.
Title: Plastidial glyceraldehyde-3-phosphate dehydrogenase deficiency leads to altered root development and affects the sugar and amino acid balance in Arabidopsis.

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NM_101496.3

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular amino acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primary root development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in plastid	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_173080.1

glyceraldehyde-3-phosphate dehydrogenase of plastid 2 (GAPCP-2); CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain, subgroup (InterPro:IPR020832), Glyceraldehyde 3-phosphate dehydrogenase, active site (InterPro:IPR020830), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde-3-phosphate dehydrogenase of plastid 1 (TAIR:AT1G79530.1); Has 25238 Blast hits to 25227 proteins in 6343 species: Archae - 51; Bacteria - 10898; Metazoa - 2382; Fungi - 2852; Plants - 3834; Viruses - 0; Other Eukaryotes - 5221 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain