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    ZWINT ZW10 interacting kinetochore protein [ Homo sapiens (human) ]

    Gene ID: 11130, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZWINTprovided by HGNC
    Official Full Name
    ZW10 interacting kinetochore proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13195
    See related
    Ensembl:ENSG00000122952 MIM:609177; AllianceGenome:HGNC:13195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP30; ZWINT1; KNTC2AP; HZwint-1
    Summary
    This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 17.2), testis (RPKM 16.4) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZWINT in Genome Data Viewer
    Location:
    10q21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (56357227..56361273, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (57207567..57211612, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (58116988..58121034, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 21 Neighboring gene zinc finger MYM-type containing 4 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:57507392-57507557 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:57581693-57582274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:57582275-57582855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:57659053-57659628 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:57659629-57660203 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:57738855-57739607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2373 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:58118905-58120104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:58120730-58121469 Neighboring gene uncharacterized LOC124902546 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:58297350-58298549 Neighboring gene small nucleolar RNA SNORD2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway. Ma Z, et al. Chin J Physiol, 2023 Sep-Oct. PMID 37929349
    2. Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery. Yang XY, et al. Technol Cancer Res Treat, 2018 Jan 1. PMID 30198401, Free PMC Article
    3. ZWINT is the next potential target for lung cancer therapy. Peng F, et al. J Cancer Res Clin Oncol, 2019 Mar. PMID 30643969
    4. ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion. Yang L, et al. Oncol Rep, 2020 Jun. PMID 32323832, Free PMC Article
    5. HZwint-1, a novel human kinetochore component that interacts with HZW10. Starr DA, et al. J Cell Sci, 2000 Jun. PMID 10806105

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
      Title: ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
    2. Genome-wide association analysis of cognitive function in Danish long-lived individuals.
      Title: Genome-wide association analysis of cognitive function in Danish long-lived individuals.
    3. Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
      Title: Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
    4. ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
      Title: ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
    5. upregulated in prostate cancer tissues
      Title: Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
    6. results suggested ZWINT as a potential gene associated with lung cancer cell proliferation
      Title: ZWINT is the next potential target for lung cancer therapy.
    7. ZW10 interactor was frequently decreased in hepatocellular carcinoma.
      Title: Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.
    8. Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis.
      Title: Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
    9. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
      Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
    10. These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
      Title: Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of localization in cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homologous chromosome orientation in meiotic metaphase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiosis I spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Knl1/Spc105 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ZW10 interactor
    Names
    SNAP25 interacting protein of 30 kDa
    ZW10 interactor, kinetochore protein
    human ZW10 interacting protein-1
    zwint-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033939.1 RefSeqGene

      Range
      5015..9047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005413.1 → NP_001005413.1  ZW10 interactor isoform b

      See identical proteins and their annotated locations for NP_001005413.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC016357, BC020979, BG615304, BM724168
      Consensus CDS
      CCDS31205.1
      UniProtKB/TrEMBL
      B4DP12
      Related
      ENSP00000354921.6, ENST00000361148.6
      Conserved Domains (1) summary
      pfam15556
      Location:29 → 230
      Zwint; ZW10 interactor

    2. NM_007057.4 → NP_008988.2  ZW10 interactor isoform a

      See identical proteins and their annotated locations for NP_008988.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and differs in the 3' UTR compared to variant 2. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AC010996, BC000411, BC016357, BC020979, BG615304
      Consensus CDS
      CCDS7249.1
      UniProtKB/Swiss-Prot
      A6NNV6, O95229, Q0D2I3, Q9BWD0
      UniProtKB/TrEMBL
      B4DP12
      Related
      ENSP00000363055.3, ENST00000373944.8
      Conserved Domains (1) summary
      pfam15556
      Location:29 → 277
      Zwint; ZW10 interactor

    3. NM_032997.3 → NP_127490.1  ZW10 interactor isoform a

      See identical proteins and their annotated locations for NP_127490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      BC000411, BC016357, BC020979, BG615304
      Consensus CDS
      CCDS7249.1
      UniProtKB/Swiss-Prot
      A6NNV6, O95229, Q0D2I3, Q9BWD0
      UniProtKB/TrEMBL
      B4DP12
      Related
      ENSP00000378801.1, ENST00000395405.5
      Conserved Domains (1) summary
      pfam15556
      Location:29 → 277
      Zwint; ZW10 interactor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      56357227..56361273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_428692.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      57207567..57211612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008488158.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005414.1: Suppressed sequence

      Description
      NM_001005414.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95229.2 GenPept UniProtKB/Swiss-Prot:O95229

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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