BCAN brevican [Homo sapiens (human)] - Gene

Summary

Official Symbol: BCANprovided by HGNC
Official Full Name: brevicanprovided by HGNC
Primary source: HGNC:HGNC:23059
See related: Ensembl:ENSG00000132692 MIM:600347; AllianceGenome:HGNC:23059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BEHAB; CSPG7
Summary: This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression: Restricted expression toward brain (RPKM 121.6) See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (156642117..156659528)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (155778497..155795916)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156611909..156629320)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort.
Title: Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort.
The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility.
Title: The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility.
The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study.
Title: The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study.
Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
Title: Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
High Brevican is associated with the invasive phenotype of low-grade astrocytoma.
Title: Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
Observational study of gene-disease association. (HuGE Navigator)
Title: Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.
The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility
Title: The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican.
Title: Human glioblastomas overexpress ADAMTS-5 that degrades brevican.
gene locus at chromosome 1q21-23.
Title: Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH63843 (e-PCR)
- UniSTS:51467

SHGC-84885 (e-PCR)
- UniSTS:104781

WI-15716 (e-PCR)
- UniSTS:54168

D1S3694 (e-PCR)
- UniSTS:474272

WI-15733 (e-PCR)
- UniSTS:77496

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse maturation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
is_active_in perineuronal net	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: brevican core protein

Names: brain-enriched hyaluronan-binding protein; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030013.1 RefSeqGene

Range

5170..22581

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_021948.5 → NP_068767.3 brevican core protein isoform 1 precursor

See identical proteins and their annotated locations for NP_068767.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL365181, AL590666, AY358372, BC027971

Consensus CDS

CCDS1149.1

UniProtKB/Swiss-Prot

D3DVC2, Q5SZ10, Q5T3I5, Q8TBB9, Q96GW7, Q9HBK1, Q9HBK4

UniProtKB/TrEMBL

A8K144

Related

ENSP00000331210.4, ENST00000329117.10

Conserved Domains (8) summary

cd00033
Location:815 → 872

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00410
Location:44 → 154

IG_like; Immunoglobulin like

cd03517
Location:157 → 251

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:258 → 353

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

pfam00008
Location:650 → 679

EGF; EGF-like domain

pfam08688
Location:483 → 558

ASD1; Apx/Shroom domain ASD1

cl02432
Location:688 → 811

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl11960
Location:49 → 158

Ig; Immunoglobulin domain
NM_198427.2 → NP_940819.1 brevican core protein isoform 2 precursor

See identical proteins and their annotated locations for NP_940819.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AF229053, AW298823, AY358372

Consensus CDS

CCDS1150.1

UniProtKB/Swiss-Prot

Q96GW7

Related

ENSP00000354925.5, ENST00000361588.5

Conserved Domains (4) summary

smart00410
Location:44 → 154

IG_like; Immunoglobulin like

cd03517
Location:157 → 251

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:258 → 353

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cl11960
Location:49 → 158

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

156642117..156659528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011509866.1 → XP_011508168.1 brevican core protein isoform X2

See identical proteins and their annotated locations for XP_011508168.1

UniProtKB/Swiss-Prot

D3DVC2, Q5SZ10, Q5T3I5, Q8TBB9, Q96GW7, Q9HBK1, Q9HBK4

UniProtKB/TrEMBL

A8K144

Conserved Domains (8) summary

cd00033
Location:815 → 872

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00410
Location:44 → 154

IG_like; Immunoglobulin like

cd03517
Location:157 → 251

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:258 → 353

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

pfam00008
Location:650 → 679

EGF; EGF-like domain

pfam08688
Location:483 → 558

ASD1; Apx/Shroom domain ASD1

cl02432
Location:688 → 811

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl11960
Location:49 → 158

Ig; Immunoglobulin domain
XM_017002047.2 → XP_016857536.1 brevican core protein isoform X1

UniProtKB/TrEMBL

A8K144