Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naa60provided by RGD
Official Full Name: N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by RGD
Primary source: RGD:1308915
See related: EnsemblRapid:ENSRNOG00000007280 AllianceGenome:RGD:1308915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HAT4; NatF; Nat15; RGD1308915
Summary: Predicted to enable histone H4 acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; chromosome segregation; and nucleosome assembly. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 117.2), Brain (RPKM 111.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (12129026..12149053, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11622554..11653078, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (11881635..11902139, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139149 (e-PCR)
- UniSTS:221235

BF405602 (e-PCR)
- UniSTS:247945

RH133439 (e-PCR)
- UniSTS:216722

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide alpha-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-methionine-alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-methionine acetylation	IEA Inferred from Electronic Annotation more info
involved_in N-terminal peptidyl-methionine acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-methionine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 60

Names: GNAT acetyltransferase; GNAT acetytransferase; N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit

NP_001014248.2

EC 2.3.1.259

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014226.2 → NP_001014248.2 N-alpha-acetyltransferase 60

See identical proteins and their annotated locations for NP_001014248.2

Status: PROVISIONAL

Source sequence(s)

BC105304

UniProtKB/Swiss-Prot

Q3MHC1, Q7TMZ6

Related

ENSRNOP00000009936.3, ENSRNOT00000009936.8

Conserved Domains (2) summary

pfam00583
Location:23 → 155

Acetyltransf_1; Acetyltransferase (GNAT) family

cl21457
Location:139 → 203

TIM; TIM-like beta/alpha barrel domains